Animal Science Faculty

 Kathy L Timms

Kathy L. Timms


Professor, Obstetrics & Gyn / Animal Sciences

Mechanisms of Infertility

Department of Obstetrics, Gynecology and Women’s Health
N625 Health Sciences
Columbia, MO 65212

Education


  • The University of Kentucky, Lexington

    Postdoctoral Fellow - Reproductive Endocrinology, Department of Obstetrics and Gynecology, Kentucky Center for Reproductive Medicine
  • The University of Tennessee, Knoxville

    Doctor of Philosophy - Animal Science-Reproductive Pathophysiology
  • Southern Illinois University, Carbondale

    Master of Science - Animal Industries-Reproductive Physiology, Department of Animal Industries

    Bachelor of Science-Zoology-Mammalian Physiology

Current Status


2005-Present

Tenured Full Professor, University of Missouri – Columbia
Department of Obstetrics, Gynecology and Women’s Health Director,
Division of Reproductive and Perinatal Research School of Medicine

Director/Embryologist, Missouri Center for Reproductive Medicine and Fertility Embryology Laboratories
University of Missouri Health Care System

Joint Appointments

Department of Animal Science
College of Agriculture, Food, and Natural Resources

Comparative Medicine Program and Dept. of Veterinary Pathobiology, Area Pathobiology Program
College of Veterinary Medicine

Certification

1994 - Present - High-Complexity Clinical Laboratory Director
American Board of Bioanalysts
St. Louis, MO

Honors and Awards


Editorial Appointments and Awards

2003 - 2007 Associate Editor for Human Reproduction

2007 - Present Associate Editor for Human Reproduction Update

2010 - Certificate of Excellent Contribution, Human Reproduction/Oxford University Press. Recognized as one of the journal’s top 10% reviewers judged by quality and timelines of reviews

Executive Appointment

1994 – 1996 Elected Director, Society for Assisted Reproductive Technology, SART Executive Council, American Society for Reproductive Medicine

2007 – 2010 American Society for Reproductive Medicine Endometriosis Special Interest Group

  • 2007: Co-founder with Drs. Rob Taylor and Dan Lebovic
  • 2007: Vice Chair – elected position
  • 2008: Chair
  • 2009: Immediate Past Chair
  • 2010: Past Chair

National Institutes of Health

1992 - NIH James A. Shannon Award, Endometriosis-associated secretory proteins

2001 - 2009 NIH SCCPRR Endometriosis Focus Group invited member

National Institutes of Health Reproductive Sciences Branch Invited Speaker

1991 Basis Pathophysiology of Endometriosis, Experimental models for evaluating endometriosis therapeutics

1995 Endometriosis 2000, Pathophysiology & Diagnosis of Endometriosis: Biochemical clues

2001 Endometriosis: Emerging Research and Intervention Strategies, Paracrine regulation of MMPs in endometriosis, Using rats as a research model for studying endometriosis

National Institutes of Health Scientific Review Panels

1996 NIH P50 Center Site Visit Team Member

1998 NICHD U54 SCCPRR Center Site Visit Team Member

1998 NICHD Special Emphasis Program Project Team Member

2000 NICHD U54 SCCPRR Center Review Panel Member

2001 NICHD ZRG1 HED-1 Special Emphasis Review Panel Member

2003 - 2004 NICHD REN Study Section Member

2004 - 2007 NICHD ICER Study Section Member

2009 NIH RC1 Challenge Award Reviewer

2010 NIH ICER Study Section Ad hoc Member (February)

2010 NIH NICHD Special Emphasis Panel ZRG1 EMNR-E (50) (March)

2010 NIH NICHD Special Emphasis Panel ZRG1 EMNR-E (10) (June)

2010 NIH NICHD Special Emphasis Panel ZRG1 EMNR E10 B (October)

Other Scientific Review Panels (Invited)

1990 Grayson‑Jockey Club Research Foundation, Lexington, KY

1995 USAMRMC, Ft. Detrick, MD

1995 North Carolina Biotechnology Center, Research Triangle Park, NC

1996 National Science Foundation, Arlington, VA

1999 University of Leuven, Leuven, Belgium Grant Reviewer

2007 The Royal Women’s Hospital, Melbourne, Australia, Invited International Expert, Service on PhD Committee of Dr. Anne Polliness

2008 UK’s National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs). Professor Ian Martin Sheldon et al (Royal Veterinary College, London. Title: Functional 3D models of the endometrium exploiting smart scaffolds

Other Honors (chronologically)

1977 – Present Phi Kappa Phi National Honor Society

1982 Young Career Woman Award
Murfreesboro Professional Women's Association

1983 Outstanding Woman of America Award
The Outstanding Americans Association

1984 - 1985 Middle Tennessee State University Faculty Educational Grant

1988, 1989 Society for the Study of Reproduction Travel Award

1989 - 1990 National Institutes of Health Contraceptive Development Branch GnRH Antagonist (Antide) for studies on endometriosis in the rat

1992 – 1994 National Institutes of Health James A. Shannon Award
Project Title: Endometriosis-associated secretory proteins

1994 Elected to membership in The Society for Gynecologic Investigation (SGI)

1996 Invited chairperson and speaker for SGI postgraduate course

1996 – 1997 Teaching Excellence Award, MU Department of Ob/Gyn

2002 MU School of Medicine Order of Socrates, an exclusive group awarded for continuing teaching excellence, Appointed as Charter Member

2007 Appointed as Vice Chairperson for newly formed Endometriosis Special Interest Group for the American Society of Reproductive Medicine

2008 The Society for the Study of Reproduction Laylor Foundation Award for oral presentation at annual meeting May 2008

2009 Head of the National Institute of Child Health and Human Development Reproductive Sciences Branch, Dr. Lou DePaolo, presents our research, “Reduced Fecundity in Female Rats with Surgically Induced Endometriosis and in Their Daughters” in his annual report to the Institute Director and Deputy Director of the National Institutes of Health as exemplary of the high caliber, high impact work from scientists in the NICHD.

2009 MU School of Medicine Order of Socrates II, for continuing teaching excellence, Appointed Member

2009 – 2010 Color Research Micrograph selected by The Society for the Study of Reproduction (Stilley et al., Biol Reprod 2009; 80:649-56) for publication in 2009-2010 calendar (Dec 2010); Supplement to Biology of Reproduction

2010 – 2011 Color Research Micrograph selected by The Society for the Study of Reproduction (Stilley et al., Biol Reprod 2010) for publication in 2010-2011 calendar (Dec 2010); Supplement to Biology of Reproduction

Patents and Licensing


1998 - Antibody against human endometrial stromal cell glycoprotein, US Serial # 5,831,035

1998 - Method of screening for endometriosis-TIMP-1, US Serial # 5,843,673

2001 - Glycoprotein for use in determining endometrial receptivity, US Serial # 6,309,843 B1

2003 - Endometriosis-specific secretory proteins-ENDO-I, US Serial # 6,531,277

2006 - Endometriosis-specific secretory protein, US Serial # 10/306,903

Postgraduate Workshops


The American Associate of Bioanalysts

1994 Embryology and Andrology Review Course. Chicago, IL
1995 State of the A.R.T. Andrology/Embryology Workshop, St. Louis, MO

The American Society for Reproductive Medicine

1990 Advanced Course on In Vitro Fertilization. Washington DC
1991 Reproductive Biology: Clinical & Basic Science Perspectives. Orlando, FL
1992 Reproductive Laboratory Accreditation. New Orleans, LA
1992 Oocytes and Embryos: Basic & Clinical Considerations. New Orleans, LA
1993 Controversies in Reproductive Biology. Montreal, Canada
1994 Assisted Reproduction Technologies Laboratory Accreditation. San Antonio, TX
1995 Oocyte/Pre-embryo Viability and ART Outcomes: Strategies for Developing Multicenter Trials. Seattle, WA
1997 Endometriosis: A View from Bench to Bedside. Cincinnati, OH
2000 Pathogenesis of Endometriosis: Bench to bedside innovations. San Diego, CA
2003 Endometriosis: A critical appraisal, Society for Reproductive Surgeons. New Orleans, LA
2005 The Future of Microfluidics and Embryo Culture. Montreal, CANADA
2005 Movin’ On Up: Building a new IVF laboratory, Montreal, CANADA
2005 Markers of Oocyte Quality, Montreal, CANADA
2007 Preimplantation genetic diagnosis, Orlando, FL

The International Conference on Human Fertility

2000 The Fourth International Conference on Human Fertility and Reproduction: the Oocyte, Embryo and Uterus. New York University School of Medicine, New York, NY

The National Institute of Child Health and Human Development

1991 Workshop on the Basic Pathophysiology of Endometriosis. Washington DC
1995 Endometriosis 2000. Washington DC
1996 Conference on Human Uterine Receptivity for Blastocyst Implantation. Bethesda, MD
2001 Endometriosis: Emerging Research and Intervention Strategies. Bethesda, MD

The Society for Gynecologic Investigation

1996 Current Concepts of Endometrial Biology, Blastocyst Interaction and Trophoblast Invasion, Philadelphia, PA
2004 Epigenetic regulation of reproductive development and function: more than just genes, Houston, TX

The World Congress on Endometriosis

1989 II World Congress, San Antonio, TX
1998 VI World Congress, Quebec City, Quebec, Canada
2002 VIII World Congress, San Diego, CA

Research


Experience

1976 – 1977 Southern Illinois University, Carbondale, IL
Department of Animal Industries
Graduate Teaching/Research Assistant
Area: Equine reproduction

1977 – 1979 Washington University Medical School, St. Louis, MO
Division of Dermatology
Senior Research Technician/Associate
Area: Collagen biosynthesis

1985 - 1987 University of Tennessee, Knoxville, TN
Department of Animal Science
Graduate Research Assistant
Area: Equine and bovine reproductive pathophysiology

1987 – 1990 University of Kentucky Medical Center, Lexington, KY
Department of Obstetrics and Gynecology
Postdoctoral Fellow in Reproductive Endocrinology
Area: Reproductive endocrinology

1990 – Present University of Missouri, Columbia, MO, Department of Obstetrics and Gynecology, Department of Animal Science

  • 1990 – 1996 Assistant Professor
  • 1996 – 2002 Associate Professor with Tenure
  • 1996 – Present Director, Division of Ob/Gyn Research
  • 2002 – Present Full Professor, Human reproductive pathophysiology

Support

External Funding: National Institutes of Health

1990 – 2010 Source: National Institutes of Health – (peer reviewed), 5T32RR007004-27
Title: NCRR T-32 Training Grant I Comparative Medicine
Role: Trainee Mentor (5%; PI: Craig Franklin, DVM)

1992 – 1994 Source: National Institutes of Health - (peer reviewed)
1 R55 HD 29026-01-02
JAMES A. SHANNON AWARD
Title: Endometriosis-Associated Secretory Proteins
Direct costs: $81,309
Indirect costs: $18,691
Total costs: $100,000
Role: PI (50% FTE)

1993 – 1998 Source: National Institutes of Health - (peer reviewed)
1 R29 HD 29026-01-05
Title: Endometriosis-Associated Secretory Proteins
Direct costs: $315,000
Indirect costs: $141,750
Total costs: $456,751
Role: PI (50% FTE)

1999 - 2000 Source: National Institutes of Health - (peer reviewed)
1 R29 HD 29026-05-A1
Office of Research for Women’s Health
Title: Endometriosis-Associated Secretory Proteins
Direct costs: $68,966
Indirect costs: $31,034
Total costs: $100,000
Role: PI (50% FTE)

2001 - 2003 Source: National Institutes of Health - (peer reviewed)
1 R21 AI055504-01
Title: Regulation of Human TLR-3 and TLR-9 Expression and Function
Direct costs: $300,000
Indirect costs: $134,100
Total costs: $434,100
Role: Co-I (5% FTE; PI: Steven L. Young, MD, PhD)

2002 – 2005 Source: National Institutes of Health, NIDDK - (peer reviewed) KO1 DK60567-01
Title: Development and use of systems to study estrogen action
Total costs: $310,275
Role: Faculty mentor, (Susan C. Nagel, PI)

2003 – 2008 Source: National Institutes of Health - (peer reviewed)
1 R01 HD 40849-01-A2
Title: Endometriotic haptoglobin alters macrophage function
Direct costs: $900,000
Indirect costs: $365,715
Total costs: $1,265,715
Role: PI (50% FTE)

2008 - 2013 Source: National Institutes of Health - (peer reviewed)
NIH 1R01 HD057445-01 A1
Title: Reduced Fecundity in Female Rats with Surgically Induced Endometriosis and in Their Daughters: A role for TIMP-1
Direct costs: $1,825,162
Indirect costs: $857,826
Total costs: $2,682,988
Role: PI (50% FTE)

2009 – 2011 Source: National Institutes of Health (peer reviewed)
NIH R21
Title: Developmental programming of endometriosis-related genes
Direct Costs: $275,000
Indirect Costs: $117,549
Total Requested $392,550
Role: Co-I (10% FTE, PI Susan Nagel)

External Funding: Other Support

1993 – 1995 Source: TAP Holdings, Inc. - (peer reviewed)
Title: Effects of the GnRH Agonist, Lupron Depot, on Adhesion Formation
Direct costs: $18,441 (drug and supplies provided)
Role: PI

1995 – 2001 Source: TAP Holdings, Inc. - (gift)
Title: Serum Markers for Endometriosis
Direct costs: $285,000
Role: PI

1996 – 1998 Source: Wallace Genetic Foundation - (reviewed by Foundation)
Title: DHEA and aging
Direct costs: $42,984
Role: Co-I (10% FTE, PI: Margaret Flynn, MD)

1998 - 1999 Source: Merck Research Laboratories – (gift)
Title: Effects of a new farnesyl transferase inhibitor on endometriotic cells
Direct costs: $5,000
Role: PI

1998 - 1999 Source: Children’s Miracle Network - (peer reviewed)
Title: Early Predictors of perinatal morbidity and mortality
Direct costs: $10,000
Role: Co-I (5% FTE, PI: Robert Fraser, MD)

1999 - Present Source: Missouri Life Sciences Mission Enhancement - (competitive award)
Title: New Initiatives in Reproductive and Developmental Biology and Genetics at the University of Missouri, Columbia
Direct costs: $4,615,000
Role: Co-author with Allen Garverick, Ph.D.

2007 – 2009 Source: March of Dimes Basil O'Connor Award
Title: Fetal programming of endometriosis-related genes is due to altered DNA methylation
Direct costs: $150,000
Role: Co-I (5 % FTE, no salary provided; PI: Susan Nagel, PhD)

Institutional Support

1990 – 1993 Source: Department of Obstetrics and Gynecology
Title: Start up monies
Direct costs: $45,000
Role: PI

1991 – 1992 Source: Research Council Grant - (peer reviewed) The University of Missouri School of Medicine
Title: Purification of endometriosis-associated secretory proteins
Direct costs: $10,000
Role: PI

1991 – 1992 Source: Weldon Springs Junior Faculty Fund Competition - (peer reviewed)
Title: Endometriosis: a novel approach toward the understanding of the pathophysiology of the disease
Direct costs: $18,226.09
Role: PI

1991, 1992, 1993, 1994, 1996, 1997, 2001, 2004, 2005, 2007
Source: MU School of Medicine
Title: Summer Student Fellowship
Total costs: $24,000
Role: Mentor

1999 Source: University of Missouri Research Board - (peer reviewed)
Title: Characterization of Endometriosis Protein-I
Direct costs: $44,500
Role: PI

2002 – 2003 Source: Research Council Grant - (peer reviewed)
The University of Missouri-Columbia
Title: Haptoglobin in Endometrial Cancer
Direct costs: $5,000
Role: PI

2004-2005 Source: Research Council Grant - (peer reviewed)
The University of Missouri-Columbia
Title: Fetal xenoestrogen exposure permanently alters endometriosis gene expression
Period: Total costs: $7,500
Role: Co-I (5% FTE, PI: Nagel)

2006 – 2007 Source: MU Research Board - (peer reviewed)
Title: Fetal programming of endometriosis-related genes
Direct costs: $30,280
Role: Co-I (5% FTE, cost shared; PI: Nagel)

2007 – 2008 Source: MU Research Board - (peer reviewed)
Title: Mechanisms of Endometriosis-Induced Infertility
Direct costs: $30,700
Role: PI (5% FTE, cost shared)

PENDING RESEARCH SUPPORT:

2011 – 2016 Source: National Institutes of Health – (peer reviewed)
1R01-1HD062017-01
Title: Anti-inflammatory and fertility-preserving curcumin analogs in endometriosis
Direct Costs: $979,987
Indirect Costs: $455,815.00
Total Costs: $1,342,633
Role: Co-PI (Multiple PI project with Robert N. Taylor and Friedrich A. Wieser at Emory University)
Status: A-1 submission October 2008, Scored 242, 46th percentile Resubmitted June 25, 2010

2011 – 2013 Source: National Institutes of Health – (peer reviewed)
New R21 application
Title: Xenoestrogen tissue specific activity predicted by estrogen receptor conformation
Direct Costs: $979,987
Indirect Costs: $455,815.00
Total Costs: $1,342,633
Role: Co-I (10%, PI: Susan Nagel)
Status: Submitted June 2010

APPLIATIONS FOR SUPPORT IN PREPARTATION:

2010 - 2012 Source: NIH Administrative Supplement to current NIH R01 Title: TIMP1 impedes ovulation via MMP-independent mechanisms

Role: PI Status: Submitted July 2010

2010 – 2011 Source: MU System Research Board – (peer reviewed)
Title: Multigenerational effects of endometriosis on fertility and early pregnancy loss – preliminary data
Role: PI
Status: For submission November 2010


2011 – 2016 Source National Institutes of Health - (peer reviewed)
1R01-
Title: Multigenerational, heritable effects of endometriosis on fertility and early pregnancy loss
Direct Costs: $2,251,416
Indirect Costs: $1,107,635
Total Requested: $3,359,051
Role: PI (50% FTE)
Status: For submission Oct 2010

2011 – 2016 Source: NIH, NIEHS R01, RFA-ES-06-007 (peer reviewed)
Title: Fetal xenoestrogen programming and exacerbation of endometriosis in adulthood
Direct costs: $1,375,000
Indirect Costs: $571,425
Total Costs: $2,196,425
Role: Co-I (7.5 % FTE, PI: Susan Nagel)
Status: For submission Nov 2010

Publications and Presentations


Peer Reviewed Articles

  1. Uitto J, Allen RE, Polak (Sharpe-Timms) KL. Conversion of type II collagen. Extracellular removal of the amino‑terminal and carboxy‑terminal extensions without preferential sequence. Eur J Biochem 1979; 99:97-103. PMID: 573690
  2. Uitto J, Booth BA, Polak (Sharpe-Timms) KL. Collagen biosynthesis by human skin fibroblasts. II. Isolation and further characterization of type I and type III procollagens synthesized in culture.Biochim Biophys Acta. 1980; 624(2):545-61.PMID: 7417491
  3. Booth BA, Polak (Sharpe-Timms) KL, Uitto J. Collagen biosynthesis by human skin fibroblasts I. Optimization of the culture conditions for synthesis of type I and type II procollagens. Biochim Biophys Acta 1980; 607:145-60. PMID: 7370260
  4. Polak (Sharpe-Timms) KL, Kammlade WG. Vaginal pH During Estrus in Mares. Theriogenology 1981; 15:271-76. PMID: 16725587
  5. Sharpe (Timms) KL, Eiler H, Hopkins FM. Absence of uterokinetic effects of prostaglandin F‑2 alpha on oxytocin reactive uterus in the mare. Theriogenology 1988; 30:887-92. PMID: 16726530
  6. Sharpe (Timms) KL, Eiler H, Cullen CC, Hopkins FM. Morphometric analysis of collagen in gestational and retained bovine placentomes. Theriogenology 1989; 32:485-91. PMID: 16726695
  7. Sharpe (Timms) KL, Eiler H, Hopkins FM. Changes in the proportion of type I and type III collagen in the developing and retained bovine placentome. Biol Reprod 1990; 43:229-35. PMID: 2378934
  8. Sharpe (Timms) KL, Bertero MC, Vernon MW. Rapid regression of endometriosis by a new gonadotropin-releasing hormone antagonist in rats with surgically induced disease. Prog Clin Biol Res. 1990; 323:449-58. PMID: 2406755
  9. Sharpe (Timms) KL, Bertero MC, Lyon BP, Muse KN, Vernon MW. Follicular atresia and infertility in rats treated with a gonadotropin-releasing hormone antagonist. Endocrinol 1990 Jul;127(1):25-31. PMID: 2113868
  10. Sharpe (Timms) KL, Bertero MC, Vernon MW. Spontaneous and steroid-induced recurrence of endometriosis following suppression by a gonadotropin‑releasing hormone antagonist in the rat. Amer J Obstet Gynecol 1991; 164:187-94. PMID: 1986606
  11. Sharpe (Timms) KL, Bertero MC, Vernon MW. Detection of a progesterone‑induced, secretory protein synthesized by the uteri but not the endometriotic implants of rats with induced endometriosis. Fertil Steril 1991; 55:403-10. PMID: 1991538
  12. Sharpe (Timms) KL, Zimmer RL, Khan RS, Penney LL. Proliferative and morphogenic changes induced by the co-culture of uterine and peritoneal cells: A cell culture model for endometriosis. Fertil Steril 1992; 58:1220-9. PMID: 1459275
  13. Sharpe (Timms) KL, Vernon MW. Polypeptides synthesized and released by rat ectopic uterine tissue differ from those of the uterus in culture. Biol Reprod 1993; 48:1334-40. PMID: 8318587
  14. Moon, CE, Bertero MB, Curry TE, London SN, Muse KN, Sharpe (Timms) KL, Vernon MW. The presence of luteinized unruptured follicle syndrome (LUFS) and altered folliculogenesis in rats with surgically induced endometriosis. Am J Ob Gyn 1993; 169:676- 82. PMID: 8372879
  15. Sharpe (Timms) KL, Zimmer RL, Griffin WT, Penney LL. Polypeptides synthesized and released by human endometriosis tissue differ from those of the uterine endometrium in culture. Fertil Steril 1993; 60(5):839-51. PMID: 7693516
  16. Sharpe-Timms KL, Bruno PL, Penney LL, Bickel JT. Immunohistochemical localization of granulocyte-macrophage colony stimulating factor (GM-CSF) in matched endometriosis and endometrial tissues. Am J Ob Gyn 1994; 171:440-5. PMID: 8092224
  17. Wright JA and Sharpe-Timms KL. Gonadotropin-releasing hormone agonist (GnRHa) therapy reduces postoperative adhesion formation and reformation following adhesiolysis in rat models for adhesion formation and endometriosis. Fertil Steril 1995; 63:1094-100. PMID: 7720924
  18. Sharpe-Timms KL, Zimmer RL, Trammell SE, Muscolino GM, Penney LL. Immunolocalization of Progesterone-Induced Uterine Protein-1, PUP-1, in human endometrium during the menstrual cycle and in the placenta throughout gestation. Am J Obstet Gynecol 1995; 173:1569-78. PMID: 7503203
  19. Sharpe-Timms KL, Penney LL, Zimmer RL, Wright JA, Zhang Y, Surewicz KS. Partial purification and amino acid sequence analysis of endometriosis protein-II (ENDO-II) reveals homology with tissue inhibitor of metalloproteinases-1 (TIMP-1). J Clin Endocrin Metab 1995; 80: 3784-7. PMID: 8530636
  20. Osteen KG, Bruner KL, Sharpe-Timms KL. Steroids and growth factor regulation of matrix metalloproteinases expression and the disease endometriosis. Sem Reprod Endocrin 1996; 14:247-255. PMID: 8885055
  21. Ramey JW, Booker SS, Kanbour-Shakir A, Campbell AE, Sharpe-Timms KL, Archer DF. Inability to establish ectopic endometrium in a natural killer cell-deficient murine model - Immunologic, histologic and histochemical assessment. J Reprod Med 1996; 41:807-14. PMID: 8951129
  22. Sharpe-Timms KL. Basic Research in Endometriosis. Obstet Gynecol Clin North Am. 1997 Jun;24(2):269-90. Review. PMID: 9163767
  23. Sharpe-Timms KL, Piva M, Ricke EA, Surewicz K, Zhang YL, Zimmer RL. Endometriotic lesions synthesize and secrete a haptoglobin-like protein. Biol Reprod 1998; 58:988-94. PMID: 9546730
  24. Sharpe-Timms KL, Keisler LW, McIntush EW, Keisler DH. Tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations are attenuated in peritoneal fluid and sera of women with endometriosis and restored in sera by gonadotropin-releasing hormone agonist (GnRHa) therapy. Fertil Steril 1998; 69(6): 1128-34. PMID: 9627304
  25. Sharpe-Timms KL, Zimmer RL, Jolliff WJ, Wright JA, Nothnick WB, Curry TE. Gonadotropin-releasing hormone agonist (GnRHa) therapy alters activity of plasminogen activators (PA), matrix metalloproteinases (MMP) and of their inhibitors (PAI and MMPI) in rat models for adhesion formation and endometriosis: potential GnRHa-regulated mechanisms reducing adhesion formation. Fertil Steril 1998; 69(5):916-23. PMID: 9591503
  26. Piva M, Sharpe-Timms KL. Peritoneal endometriotic lesions differentially express a haptoglobin-like gene. Molecular Human Reprod 1999; 5: (1):71-78. PMID: 10050665
  27. Flynn MA, Weaver-Osterholtz D, Sharpe-Timms KL, Allen S, Krause G. Dehydroepiandrosterone replacement in aging humans. J Clin Endocrin Metabol 1999, 84:1527-33. PMID: 10323374
  28. Sharpe-Timms KL, Glasser S. Models for the study of uterine receptivity for blastocyst implantation. Seminars in Reprod Endocrin 1999; 17:107-15. Review. PMID: 10406080
  29. Sharpe-Timms KL, Ricke EA, Piva M, Horowitz GM. Differential in vivo expression and localization of endometriosis protein-I (ENDO-I), a haptoglobin homologue, in endometrium and endometriotic lesions. Human Reproduction, 2000; 15(10):2180-5. PMID: 11006195
  30. Cox KE, Sharpe-Timms KL, Kamiya N, Saraf M, Donnelly KM, Fazleabas AT. Differential regulation of stromelysin–1 (matrix metalloproteinase-3) and matrilysin (matrix metalloproteinase-7) in baboon endometrium. J Soc Gynecol Invest, 2000; 7:242-8. PMID: 10964024
  31. Piva M, Horowitz GM, Sharpe-Timms KL. Interleukin-6 differentially stimulates haptoglobin production by peritoneal and endometriotic cells in vitro: a model for endometrium-peritoneum interaction in endometriosis. J Clin Endocrin Metab 2001; 86:2553-61. PMID: 11397854 [Selected for publication in special June 2001 issue devoted, in part, to the theme of The Endocrine Society Annual Meeting, “Hormones and Reproductive Health.”]
  32. Cox KE, Piva M, Sharpe-Timms KL. Differential regulation of matrix metalloproteinase-3 gene expression in endometriotic lesions as compared to endometrium. Biol Reprod 2001; 65: 1297-303. PMID: 11566756
  33. Sharpe-Timms KL. Endometrial anomalies in women with endometriosis. Ann NY Acad Sci, 2001; 934:131-47. PMID: 11594534
  34. Sharpe-Timms KL, Cox, K. Paracrine regulation of matrix metalloproteinase expression in endometriosis. Ann NY Acad Sci 2002; 955:147-56. PMID: 11949944
  35. Sharpe-Timms KL. Using rats as a research model for the study of endometriosis. Ann NY Acad Sci 2002; 955:318-27. PMID: 11949958
  36. Barrier BF, Sharpe-Timms KL. Expression of soluble adhesion molecules in sera of women with stage III and IV endometriosis. J Soc Gyn Invest 2002; 9:98-101. PMID: 11963839
  37. Sharpe-Timms KL, Zimmer RL, Ricke EA, Piva MA, Horowitz GM. Endometriotic haptoglobin binds peritoneal macrophages and alters their function in endometriosis. Fertil Steril; 2002; 78:810-819. PMID: 12372461 [Selected for Publication in Special Endometriosis Issue].
  38. Piva MA, Moreno I, Sharpe-Timms KL. Glycosylation and over-expression of endometriosis-associated peritoneal haptoglobin. Glycoconj J 2003; 19(1):33-41. PMID: 12652078
  39. Sharpe-Timms KL, Young SL. Understanding Endometriosis: the key to successful therapeutic management. Fertil Steril 2004; 81(5): 1201-3. PMID: 15136076
  40. Sutovsky P, Manandhar G, Laurincik J, Letko J, Camano JN, Day BN, Lai L, Prather RS, Sharpe-Timms KL, Zimmer R, Sutovsky M. Expression and proteasomal degradation of the major vault protein (MVP) in mammalian oocytes and zygotes. Reproduction. 2005; 129(3):269-82:1-15. PMID: 15749954. Selected for Cover Image.
  41. Sharpe-Timms, KL. Haptoglobin expression by shed endometrial tissue fragments found in peritoneal fluid. Fertil Steril 2005; 84(1):22-30:35-7. PMID: 16009149
  42. Sharpe-Timms, KL. Defining endometrial cells: the need for improved identification at ectopic sites and characterization in eutopic sites for developing novel methods of management for endometriosis. Fertil Steril 2005; 84(1):35-7; discussion 38-9:22-30. PMID: 16009152
  43. Barrier BF, Kendall BS, Sharpe-Timms KL, Kost ER. Characterization of human leukocyte antigen-G (HLA-G) expression in endometrial adenocarcinoma. Gynecol Oncol. 2006;103(1):25-30. Epub 2006 Mar 10. PMID: 16530254
  44. Barrier BF, Kendall BS, Ryan CE, Sharpe-Timms KL. HLA-G is expressed by the glandular epithelium of peritoneal endometriosis but not in eutopic endometrium. Hum Reprod. 2006; 21(4):864-9. Epub 2005 Nov 25.
  45. Hegedűs B, Marga F, Jakab K, Sharpe-Timms KL, Forgács G. The interplay of cell-cell and cell-matrix interactions in the invasive properties of brain tumors. Biophysical J 2006; 91(7):1-9. PMID: 16829558
  46. Cameo P, Szmidt M, Strakova Z, Mavrogianis P, Sharpe-Timms KL, Fazleabas AT. Decidualization regulates the expression of the endometrial chorionic gonadotrophin receptor in the primate. Biol Reprod. 2006; 75:681-9. Epub 2006, Jul 12. PMID: 16837644
  47. Stilley JAW, Woods-Marshall R, Sutovsky M, Sutovsky P, Sharpe-Timms KL. Reduced fecundity in female rats with surgically-induced endometriosis and in their daughters: A potential role for Tissue Inhibitors of Metalloproteinase 1. Biol Reprod 2009; 80:649-656. Epub 2008 Nov 19. PMID: 19020297
  48. Pelch KE, Schroder AL, Kimball PA, Sharpe-Timms KL, Davis JW, Nagel SC. Aberrant gene expression profile in a mouse model of endometriosis mirrors that observed in women. Fertil Steril 2010; 93 (5):1615-1627.e18. E-pub 2009, May 1. PMID: 19473656
  49. Nabli H, Tuller E, Sharpe-Timms KL. Haptoglobin expression in endometrioid adenocarcinoma of the uterus. Reproductive Sciences. Reprod Sci. 2010; 17(1):47-55. Epub 2009, Oct 2. PMID: 19801537
  50. Sharpe-Timms KL, Nabli H, Zimmer RL, Birt JA, Davis JW. Inflammatory cytokines upregulate human endometrial haptoglobin production in women with endometriosis. Hum Reprod. 2010; 25(5):1241-50. Epub 2010 Feb 22. PMID: 20176595
  51. Stilley JAW, Birt JA, Nagel SC, Sutovsky M, Sutovsky P, Sharpe-Timms KL. Neutralizing TIMP1 restores fecundity in a rat model of endometriosis and treating control rats with TIMP1 causes anomalies in ovarian function and embryo development. Biol Reprod 2010; 83:185–194.Epub 2010, April 21. PMID: 20410455
  52. Sharpe-Timms KL, Zimmer R, Nabli H. Endometrial haptoglobin alters macrophage function, favoring the establishment of endometriosis. Human Reprod in preparation for submission Aug 2010.
  53. Sharpe-Timms KL, Wilken JA, Bedows E. Endometrial matrix metalloproteinase (MMP) activity is abrogated by low bioactivity chorionic gonadotropin (CG). J Soc Gynecol Invest; in preparation.
  54. Sharpe-Timms KL, Marshall, R., Stilley JA, Birt J. Endometriosis subfertility is epigenetically transmitted from mother to fetus. In preparation.
  55. Birt JA, Stilley JAW; Sharpe-Timms KL. Upregulation of early growth response protein (EGR-1) in the ovaries of rats with surgically-induced endometriosis. Development, in preparation.
  56. Sharpe-Timms, KL, Marshall, R. Development of a novel comparative species microarray for translation of diagnostic data from an animal model to women with endometriosis. Biotechniques, in preparation.

Invited Book Chapters, Postgraduate Course Syllabi, Continuing Education Manuals, Instructional Videos, and Internet Web Site Contributions

  1. Sharpe (Timms) KL, Bertero MC, Vernon MW. Rapid regression of endometriosis by a new gonadotropin‑releasing hormone antagonist in rats with surgically induced disease. In: Chada DR and Buttram VC (eds.) Current Concepts in Endometriosis. New York: Alan R. Liss, Inc. 1990; 449-58.
  2. Sharpe (Timms) KL. The Pro's and Con's of Embryo/Somatic Cell Co-Culture. Postgraduate Course Syllabus, The American Fertility Society, New Orleans, LA; October 1993
  3. Sharpe-Timms KL. Embryo Culture, Assessment and Transfer. Embryology and Andrology Review Course Manual, American Association of Bioanalysts Laboratory Director Review Course, Chicago, IL; August 1994
  4. Sharpe-Timms KL. Experiences of a Reproductive Laboratory AFS/CAP Inspectee. Postgraduate Course Syllabus, The American Fertility Society, San Antonio, Texas; November 1994
  5. Sharpe-Timms KL. ENDOMETRIOSIS. TIME Life Medical Series Video Productions, TIME Warner Inc. Ed: C. Everett Koop, M.D. 1996
  6. Sharpe-Timms KL. Pros and Cons of Experimentation using in vitro models. Postgraduate course syllabus, The Society for Gynecologic Investigation: Current concepts of endometrial biology, blastocyst interaction and trophoblast invasion in implantation: in vivo biology and in vitro models for research; Philadelphia, PA, March 1996
  7. Sharpe-Timms KL. In Vitro Models for Endometriosis. In: Diamond MP, Osteen KG (eds.) Endometrium and Endometriosis. Cambridge, MS: Blackwell Science, Inc. 1997: 14:98-113.
  8. Sharpe-Timms KL. Endometriosis-derived cells: what can we learn in vitro. Postgraduate Course syllabus, The American Society of Reproductive Medicine, Cincinnati, OH 1997
  9. Sharpe-Timms KL. The diagnosis of endometriosis: new horizons. Postgraduate Course syllabus, American Society of Reproductive Medicine, Cincinnati, OH 1997
  10. Sharpe-Timms KL, Piva M, Ricke EA, Cox KE, Zimmer RL. Synthesis and secretion of a haptoglobin-like protein by peritoneal endometriotic lesions. In: Lemay A, Maheux R (eds.) Understanding and Managing Endometriosis. Advances in Research and Practice. Proceedings of the VI World Congress of Endometriosis. Lancaster, UK: Parthenon Publishing, 1999.
  11. Sharpe-Timms KL. Endometriosis Associated Secretory Proteins: their role in the pathogenesis of endometriosis and clinical management of this disease. Yourdoctor.com 2000.
  12. Sharpe-Timms KL, Zimmer RL. Oocyte and pre-embryo classification. In: Keel B, May J, DeJonge C (eds.): Handbook of the Assisted Reproductive Laboratory. CRC Press, Boca Raton, FL. 2000
  13. Sharpe-Timms KL, Piva M. Endometrial paradigms: potential assets and deficits. In: Glasser S, Aplin J, Giudice L, Tabibzadeh S (eds.) The Endometrium. Hardwood Academic Publishers gmbh, Reading, UK, 2001, Chapter 28, pp. 432-37.
  14. Sharpe-Timms KL. Revisiting the Origins of Endometriosis: A Basic Scientist’s Perspective. In: Endometriosis: A Critical Appraisal. Post Graduate Course Syllabus, The American Society for Reproductive Medicine, New Orleans, LA, October 2003
  15. Sharpe-Timms KL, Barrier B, Nagel S. Endometrial paradigms: potential assets and deficits. In: Glasser S, Aplin J, Giudice L, Tabibzadeh S (eds.) The Endometrium. Hardwood Academic Publishers gmbh, Reading, UK, 2008.
  16. Sharpe-Timms KL. Development of Department of Ob, Gyn and Women’s Health Division of Reproductive and Perinatal Research Web Site. University of Missouri-Columbia 2008 - 2009

Peer Reviewed Abstracts:

  1. Uitto J, Allen RE, Polak (Sharpe-Timms) KL. Extracellular conversion of type II procollagen to collagen. Fed Proc 1978; 37:1435.
  2. Uitto J, Polak (Sharpe-Timms) KL, Booth B. Synthesis and secretion of type I and type III procollagens by human skin fibroblasts in culture. Clin Res 1979; 27:246.
  3. Sharpe (Timms) KL, Eiler H, Hopkins FM. Effects of prostaglandin F-2 alpha and oxytocin on equine uterokinetics. Soc Study Reprod, 1987; 36:83, Champaign, IL
  4. Sharpe (Timms) KL, Eiler H, Hopkins FM. Persistency of type III collagen in the cotyledon of experimentally retained bovine placenta. 68th Annual Meeting of the Conference of Research Workers in Animal Disease, 1988; O-106, Chicago, IL
  5. Sharpe (Timms) KL, Eiler H, Cullen WC. Morphometric analysis of collagen in gestational and experimentally retained bovine placentas. Soc Study Reprod, 1988; 38:134, Seattle, WA
  6. Vernon MW, Sharpe (Timms) KL, Bertero MC, Malempati S, Wilson ML. Temporally altered synthesis of prostaglandin F by endometriotic implants in rats with surgically-induced disease. Soc Gynecol Invest, 1989; P-117, San Diego, CA.
  7. Sharpe (Timms) KL, Bertero MC, Vernon MW. Production of a unique secretory protein in rats with surgically-induced endometriosis. Soc Gynecol Invest, 1989; P-118, San Diego, CA.
  8. Sharpe (Timms) KL, Bertero MC, Miller RL, Painter AG, Case EA, Vernon MW. Rapid regression of endometriosis by a new gonadotropin‑releasing hormone antagonist in rats with surgically-induced disease. Second World Congress on Endometriosis, 1989; O-008, Houston, TX.
  9. Sharpe (Timms) KL, Bertero MC, Vernon MW. Absence of a progesterone-associated uterine secretory protein (PUP-1) in the endometriotic implant of rats with surgically-induced disease. Amer Fertil Soc, 1989; P-081, San Francisco, CA.
  10. Sharpe (Timms) KL, Bertero MC, Muse KN, Vernon MW. Rapid recurrence of endometriosis after complete suppression by a gonadotropin‑releasing hormone antagonist in the rat model. Amer Fertil Soc, 1989; O‑031, San Francisco, CA.
  11. Sharpe (Timms) KL, Bertero MC, Miller RL, Painter AC, Case EA, Vernon MW. Detection of a progesterone-associated uterine secretory protein (PUP-1) in the rat. Soc Study Reprod, 1989; Lexington, KY.
  12. Sharpe (Timms) KL, Bertero MC, Lyon BP, Vernon MV. GnRH antagonist (Antide) induced follicular atresia and infertility in rats with surgically induced endometriosis. Soc Gynecol Invest, 1990; P-237, St. Louis, MO
  13. Bertero MC, Sharpe (Timms) KL, Vernon MW. Suppression of surgically induced endometriosis in rats by various types of pseudopregnancy. Amer Fertil Soc, 1990; P-021 , Washington D.C.
  14. Sharpe (Timms) KL, Bertero MC, Homm RJ, Vernon MW. Effects of exogenous steroid administration on GnRH antagonist‑suppressed endometriosis in the rat. Amer Fertil Soc, 1990; O-103, Washington D.C.
  15. Moon CE, Bertero MC, Curry TE, London SN, Muse KN, Pedigo NG, Sharpe (Timms) KL, Vernon MW. The presence of luteinized unruptured follicle syndrome (LUFS) in rats with surgically induced endometriosis. Soc Gynecol Invest, 1991; P-470, San Antonio, TX.
  16. Bertero MB, Sharpe (Timms) KL, Moon CE, Vernon MW. Fetal loss during early pregnancy in rats with surgically-induced endometriosis. Amer Fertil Soc, 1991; O-079, Orlando FL.
  17. Sharpe (Timms) KL, Zimmer RL, Patel DD, Penney LL. Asynchronous synthesis and secretion of a progesterone-induced uterine protein, PUP-1, by endometriotic implants from rats with surgically-induced endometriosis. Soc Gynecol Invest, 1992; P-412, San Antonio, TX.
  18. Sharpe (Timms) KL, Zimmer RL, Khan RS, Penney LL. Proliferative and morphological changes induced by the co-culture of uterine and peritoneal epithelial and stromal cells; a cell culture model for endometriosis. Soc Gynecol Invest, 1992; P-411, San Antonio, TX.
  19. Sharpe (Timms) KL, Zimmer RL, Fisher MN, Khan RS. Oviduct cell monolayers enhance in vitro embryogenesis through the 2- to 4-cell developmental block in the rat. Soc Study Reprod, 1992; P-467, Chapel Hill, NC.
  20. Sharpe (Timms) KL, Zimmer, RL, Penney LL, Griffin, WT. The synthesis and release of endometriotic secretory proteins differs from that of the uterine endometrium; a qualitative comparison. Amer Fertil Soc, 1992; O-32, New Orleans, LA.
  21. Sharpe (Timms) KL, Zimmer RL, Patel DD. Synthesis and secretion of the progesterone-induced uterine protein, PUP-1, during early pregnancy in the rat. Soc Study of Reprod, 1993; P-233, Fort Collins, CO.
  22. Sharpe (Timms) KL, Zimmer RL. Effects of the progesterone antagonist Onapristone (ZK 98.299) on synthesis and secretion of the progesterone uterine protein, PUP-1, in the rat. Amer Fertil Soc, 1993; P-271, Montreal, Quebec, Canada.
  23. Sharpe (Timms) KL, Bruno PL, Kasper, KL, Trammel SE, Bickel JT. Immunohistochemical localization of granulocyte-macrophage colony stimulating factor in matched endometriotic and uterine tissues. Soc Gynecol Invest, 1994; P-35, Chicago, IL.
  24. Wright JA, Sharpe (Timms) KL. Adhesion formation in rats with surgically-induced endometriosis. Amer Assoc Lab Ani Sci, Contemporary Topics in Lab Anim Sci, 1994; 33;34:17, Pittsburgh, PA.
  25. Sharpe (Timms) KL, Zimmer RL, Trammell SL, Penney LL. Immunolocalization of progesterone-induced uterine protein, PUP-1, in human endometrium and in endometrial epithelial and stromal cell cultures. Soc Study Reprod, 1994; P-26, Ann Arbor, MI.
  26. Wright JA, Sharpe (Timms) KL. Gonadotropin-releasing hormone agonist (GnRH) therapy reduces postoperative adhesion formation and reformation following adhesiolysis in rat models for adhesion formation and endometriosis. Amer Fertil Soc, 1994; O-119, Nominated for the Society of Reproductive Surgeons Prize Paper Award, San Antonio, TX.
  27. Sharpe (Timms) KL, Muscolino GM, Trammel SL, Bickel JT. Immunohistochemical localization of the progesterone-induced uterine protein, PUP-1, in the human decidua and trophoblast during gestation. Amer Fertil Soc, 1994; P-292, San Antonio, TX.
  28. Sharpe-Timms KL, Zimmer RL, Wright JA, Zhang Y, Surewicz K. Partial purification and subsequent amino acid sequence analysis of Endometriosis Protein Group-2 (ENDO-2) reveals homology with tissue inhibitor of metalloproteinases-1 (TIMP-1). Soc Study Reprod, 1995; P-68, Davis, CA.
  29. Keisler L, Keisler DH, McIntush EW, Surewicz K, Nothnick WB, Penney LL, Sharpe-Timms KL. Tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations are reduced in peritoneal fluid of women with pelvic endometriosis, pain, or infertility. Soc Gynecol Invest, 1996; P-270, Philadelphia, PA.
  30. Sharpe-Timms KL, Zimmer RL, Zhang YL, Surewicz K, Penney L.L. Partial purification and amino acid sequence analysis of rat and human progesterone-induced uterine protein-1 reveals homology with 72 kDa gelatinase A. Soc Gynecol Invest, 1996; O-133, Philadelphia, PA.
  31. Zhang YL, Wright JA, Sharpe-Timms KL. Steroid-modulated production of a2-macroglobulin by cultured rat endometrial stromal cells. Soc Gynecol Invest, 1996; P-260, Philadelphia, PA.
  32. Nagel SC, vom Saal FS, Sharpe-Timms KL, Welshons WV. A new method using saturation analysis indicates that 0.05% of estradiol is free in human cord serum. Endocrine Society, 1996, P3-401, San Francisco, CA.
  33. Sharpe-Timms KL, Surewicz K, Chwalisz K, Donnelly KM, Fazleabas AT. Synthesis and secretion of progesterone (P)-induced uterine protein-1 (PUP-1) by the endometrium from cycling, steroid-treated and simulated-pregnant baboons (Papio anubis). Soc Study Reprod, 1996; O-183, London, Ontario.
  34. Zhang YL, Zimmer RL, Sharpe-Timms KL. Synthesis and secretion of endometriosis protein-I (ENDO-I) by peritoneal cells is augmented by co-culture with endometrial cells. Soc Study Reprod, 1996; P-90, London, Ontario.
  35. Sharpe-Timms KL, Zhang YL, Surewicz K. Amino acid sequence and cDNA sequence analyses of endometriosis protein-I (ENDO-I) reveal homology with haptoglobin-related protein. Amer Soc for Reprod Med, 1996; P-93. Boston, MA.
  36. Zhang YL, Sharpe-Timms KL. Co-culture of endometrial with peritoneal cells alters secretory activity: an electron microscopy study. Amer Soc for Reprod Med, 1996; P-107, Boston, MA.
  37. Sharpe-Timms KL, Muscolino GM, Bruner KL, Osteen KG. Differential expression and localization of tissue inhibitor of metalloproteinase-1 (TIMP-1) in endometrium and endometriosis. Amer Soc for Reprod Med, 1996; O-69, Boston, MA.
  38. Sharpe-Timms KL, Zhang YL, Surewicz. Nucleotide sequence analysis of progesterone-induced protein-1 (PUP-1) reveals homology with pro-matrix metalloproteinase-2 (proMMP-2). Soc Gynecol Invest 1997; O-100, San Diego, CA.
  39. Keisler LW, Keisler DH, Sharpe-Timms KL. Tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations are attenuated in sera of women with endometriosis and restored by GnRH agonist therapy. Soc Gynecol Invest 1997; P-594, San Diego, CA.
  40. Cox KE, Surewicz K, Sharpe-Timms KL. In vitro steroid regulation of progesterone-induced uterine protein-1 (PUP-1) in rat endometrial stromal cells. Soc Study Reprod 1997, P-407. Portland, OR
  41. Sharpe-Timms KL, Zimmer RL, Jolliff WJ, Wright JA, Nothnick WB, Curry TE. Gonadotropin-releasing hormone agonist (GnRHa) therapy alters activity of plasminogen activators (PA), matrix metalloproteinases (MMP) and of their inhibitors (PAI and MMPI) in rat models for adhesion formation and endometriosis: potential GnRHa-regulated mechanisms reducing adhesion formation. Amer Soc Reprod Med, 1997; Nominated for the Society of Reproductive Surgeons Prize Paper Award, Cincinnati, OH
  42. May JT, Sharpe-Timms KL. Lack of consensus in human oocyte grading among ART laboratory personnel. J Assist Reprod Genetics 1997; 14 (5S):OC-19-168.
  43. Piva M, Gisi PJ, Sharpe-Timms KL. Human endometriosis differentially expresses a haptoglobin-like protein. Soc Gynecol Invest 1998; O-17 Atlanta, GA.
  44. Cox KE, Piva MA, Gisi PJ, Sharpe-Timms KL. Differential expression of matrix metalloproteinase-3 (MMP-3 or stromelysin-1) in endometrium versus endometriosis. Soc Gynecol Invest 1998; P-297 Atlanta, GA.
  45. Piva M, Knitting RA, Griffin WT, Sharpe-Timms KL. Interleukin-6 (IL-6) up regulates expression of Endometriosis Protein-I (ENDO-I) mRNA, a haptoglobin-like gene that is differentially expressed by pelvic endometriosis. Amer Soc Reprod Med 1998; O-171 San Francisco, CA.
  46. Barrier BF, Sharpe-Timms KL. Expression of Soluble Adhesion Molecules in Sera of Women with Moderate to Severe Endometriosis. Soc Gynecol Invest 1999; P-681, Atlanta, GA
  47. Piva MA, Horowitz GM, Sharpe-Timms KL. Human peritoneal endometriotic lesions express all three haptoglobin "-chain phenotypes. Soc Study Reprod 1999; P-542, Portland, OR
  48. Cox KE, Sharpe-Timms KL, Kamiya N, Saraf M, Donnelly K, Fazleabas AT. Stromelysin-1 (MMP-3) expression by baboon endometrium is not directly regulated by progesterone suppression. Soc Study Reprod 1999; O-407, Pullman, WA
  49. Sharpe-Timms KL, Ricke EA, Horowitz GH. In vivo expression and localization of haptoglobin in endometrium and endometriotic lesions. Amer Soc Reprod Med 1999; P-380, Toronto, Canada
  50. Piva M, Sharpe-Timms KL. Differential glycosylation and altered lectin binding of endometrial recombinant endometriosis protein-I vs hepatic haptoglobin. Soc Gynecol Invest 2000; P-641, Chicago, IL
  51. Sharpe-Timms KL, Piva M, Ricke EA. Extrahepatic vs. hepatic haptoglobin in women with endometriosis. Soc Gynecol Invest 2000; P-825, Chicago, IL
  52. Sharpe-Timms KL, Cox KE, Ray B, Lessey BA. Localization of matrix metalloproteinase (MMP) enzymes, MMP-2 and MMP-3, to luminal endometrial epithelia by interaction with avb3 and avb5 integrins during the window of implantation. 33rd Annual Meeting Soc Study Reprod, Madison WI. Biol Reprod 2000; 62 (Suppl 1): 282, #447.
  53. Sharpe-Timms KL, Zimmer RL, Ricke EA, Horowitz GM. Aberrant adherence of peritoneal macrophages in endometriosis. Am Soc Reprod Med 2000; O-57, San Diego, CA
  54. Piva M, Horowitz GM, Sharpe-Timms. Interleukin-6 differentially stimulates haptoglobin production by peritoneal and endometriotic cells in vitro: a model for endometrium-peritoneum interaction in endometriosis. Soc Gynecol Invest 2001; P-429, Toronto, CA
  55. Sharpe-Timms KL, Zimmer RL, Ricke EA, Piva MA, Horowitz GM. Haptoglobin binds to and alters peritoneal macrophage interleukin-6 production in endometriosis. Soc Gynecol Invest 2001; P-431, Toronto, CA
  56. Young SL, Nowicki BJ, Sharpe-Timms KL. Loss of temporal expression of decay accelerating factor in eutopic and ectopic endometrium from women with endometriosis. Soc Gynecol Invest 2001; P-434, Toronto, CA
  57. Sharpe-Timms KL, Horowitz GM. Haptoglobin expression by retrogradely shed endometrial tissues may prevent eradication by peritoneal macrophages. Am Soc Reprod Med 2001; O-172, Orlando, FL
  58. Sensiboy DB, Sharpe-Timms KL. Progesterone affects cervical characteristics prior to embryo transfer. Am Soc Reprod Med 2001; P-331, Orlando, FL
  59. Fick A, Fraser R, McAsey M, Timms, KL. Maternal Serum Inhibin-A in pregnancies with fetal growth restriction. Soc Maternal Fetal Med 2002, P-584, New Orleans, LA
  60. (Sharpe-) Timms KL, Rodabaugh KJ. Endometrial tumors express haptoglobin: a pre-clinical investigation. Soc Gynecol Invest 2002, P-862, Los Angeles, CA
  61. Sharpe-Timms KL, Zimmer RL, Ricke EA. Intense focal expression of de novo synthesized haptoglobin by subluminal endometrial stroma correlates with the window of implantation in women with endometriosis. Am Soc Reprod Med 2002, O-231, Seattle WA
  62. Sharpe-Timms KL, Wilken JA, Bedows E. Endometrial matrix metalloproteinase (MMP) activity is abrogated by low bioactivity chorionic gonadotropin (CG). Soc Gynecol Invest 2003, O-321, Washington, D.C.
  63. Barrier BF, Kendall BS, Sharpe-Timms KL. HLA-G is expressed by glandular epithelium of peritoneal and ovarian endometriosis, but not in surgically induced incisional endometriosis; evidence for differential pathogenic mechanisms. Soc Gynecol Invest 2004, P-217, Houston, TX
  64. Szmidt M, Cameo P, Mavrogianis P, Sharpe-Timms KL, Fazleabas AT. Regulation of the Endometrial Chorionic Gonadotrophin Receptor (CGR) during the menstrual cycle and early pregnancy in the baboon. Soc Gynecol Invest 2005, O-328, Los Angeles, CA
  65. Sharpe-Timms KL, Shank C, Zimmer RL, Szmidt M, Fazleabas, AT. Aberrant expression of the endometrial chorionic gonadotrophin receptor (CGR) during the window of implantation in women with endometriosis: insight into reduced fertility. Soc Gynecol Invest 2005, P-749, Los Angeles, CA
  66. Pang P-C, Drobnis EZ Sutovsky P, Morris HR, Lattanzio FA, Sharpe-Timms KL, Dell A, Clark, GF. The expression of bisecting type N-glycans and ligands for DC-SIGN on human sperm. Soc Glycobiol 2006.
  67. Lwin LK, Lyddon TD, Zimmer RL, Barrier B, Sharpe-Timms KL. Haptoglobin from peritoneal fluid of women with endometriosis differentially regulates macrophage cytokine production compared to controls. Soc Gynecol Invest 2006. P-379, Toronto, Canada
  68. Sharpe-Timms KL, R.L. Zimmer, H. Nabli. Inflammatory cytokines differentially up-regulate haptoglobin expression by endometrial stromal cells from women with endometriosis compared to disease-free controls. Soc Gynecol Invest 2006. P-375, Toronto, Canada
  69. Barrier, BF, Kendall BS, Sharpe-Timms KL, Kost ER. Human leukocyte antigen-G (HLA-G) is expressed by endometrial adenocarcinoma: in utero expression correlates with the presence of metastatic disease. Soc Gynecol Invest 2006. P- Toronto, Canada
  70. Ghormley, A.L., Hurrelmeyer, K.E., Sharpe-Timms, K.L., and Nagel, S.C. Prenatal exposure to xenoestrogens and the development of endometriosis in adulthood. Amer Assoc Advance Sci 2006. St. Louis, MO.
  71. Hurrelmeyer KE, Ghormley AL, Sharpe-Timms KL, Nagel SC. Prenatal exposure to DES permanently programs expression of TIMP-1 in a mouse endometriosis model. Biol Reprod 2006; O-140 Omaha, NE.
  72. Pang P-C, Drobnis E, Sutovsky P, Morris HR, Lattanzio FA, Sharpe-Timms KL, Dell A, Clark GF. The expression of bisecting type N-glycans and ligands for DC-SIGN on human sperm. Society Glycobiol 2006; 16: 1161, P-299.
  73. Woods-Marshall R, Weaver JA, Sutovsky P, Sutovsky M, Sharpe-Timms KL. Anomalous oocyte quality and embryo development in rats with surgically-induced endometriosis and their offspring which had no surgical intervention. Soc Gynecol Invest 2007; P-72, Reno, NV
  74. Nagel SC, Hurrelmeyer KE, Sharpe-Timms KL, Schroder AL, Redel JM, Ghormley AL, Myears H. Developmental exposure to DES permanently programs TIMP-1 gene expression and exacerbates endometriosis in a mouse model. Soc Gynecol Invest 2007 P-71, Reno, NV.
  75. Weaver, JA, Woods-Marshall R, Sutovsky P, Sutovsky M, Critser J, Sharpe-Timms KL. TIMP-1 contributes to anomalies in ovarian function and pre-implantation embryo development in a rat model of endometriosis. MU Life Sciences Day, April 16, 2007, Columbia, MO
  76. Redel JM, Schroder AL, Hurrelmeyer KE, Ghormley AL, Griffith CS, Sharpe-Timms KL, Nagel SC. Developmental exposure to xenobiotic estrogen may alter the adult immune response and exacerbate endometriosis in mice. MU Life Sciences Poster Competition, April 16, 2007.
  77. Lwin LK, Lyddon TD, Zimmer RL, Barrier B, Sharpe-Timms KL. Haptoglobin from peritoneal fluid of women with endometriosis differentially regulates macrophage cytokine production compared to controls. MU Undergraduate Research and Creative Opportunities Forum, April 30, 2007, Columbia, MO
  78. Hurrelmeyer KE, Sharpe-Timms KL, Schroder AL, Redel JM, Ghormley AL Myears H, Nagel SC. Developmental exposure to xenobiotic estrogens permanently programs expression of extracellular matrix and adhesion molecules in a mouse model of endometriosis. Soc Study Reprod, San Antonio, TX, 2007.
  79. Stilley JAW, Sutovsky P, Sharpe-Timms KL. TIMP-1 causes anomalies reproductive anomalies in endometriosis. MU Animal Sciences Graduate Forum, The University of Missouri-Columbia, April 25, 2008
  80. Stilley JAW, Marshall RA, Sutovsky P, Sharpe-Timms KL. TIMP-1 contributes to anomalies in the ovary and preimplantation embryo development in a rat model of endometriosis. Soc Study Reprod 2008 Kona, HI. Oral presentation. Received Laylor Scientific Merit Award.
  81. Sabharwal, M, Birt J, Stilley J, Sharpe-Timms KL. Spontaneous pregnancy loss in endometriosis: when is the process initiated? 2008. Office of Medical Research Summer Fellowship Program. MU School of Medicine, Columbia, MO. 2009
  82. Wieser W, Yu J, Sharpe-Timms KL, Sidell N, Taylor RN. Effects of a curcumin analog, EF24, on reproductive function in rats. Soc Study Reprod 2009 Pittsburg, PA
  83. Aubuchon M, Vonderhaar EK, Timms KL, Cassels JW, Schust DJ. Effects of Partner Smoking and Alcohol Use on Pregnancy Rates in Couples Receiving Treatment for Recurrent Pregnancy Loss. Soc Gynecol Invest 2010 P, Orlando, FL. Repro Sci 2010; 17; 10(3) (suppl) 429.
  84. Birt J, Stilley JAW; Sharpe-Timms KL. Upregulation of Early Growth Response Protein 1 (Egr-1) Gene Expression in Ovaries of Rats with Endometriosis. Soc Gynecol Invest 2010 P 110, Orlando, FL. Repro Sci 2010; 17:10(3) (suppl) 110.
  85. Birt J, Stilley JAW; Sharpe-Timms KL. Upregulation of Early Growth Response Protein 1 (Egr-1) Gene Expression in Ovaries of Rats with Endometriosis. MU Animal Science Graduate Forum, 2010. Awarded 1st place in poster division.

Invited Presentations:

National and International Presentations

1989 The II World Congress on Endometriosis, Houston, TX
Title: Rapid regression of endometriosis by a new gonadotropin releasing hormone antagonist in rats with surgically-induced disease

1991 The National Institutes of Health: Workshop on the Basic Pathophysiology of Endometriosis, Washington DC
Title: Experimental Models for the Evaluation of Therapeutic Modalities for Endometriosis

1993 The American Fertility Society Postgraduate Course: Controversies in Reproductive Biology, New Orleans, LA
Title: The Pro's and Con's of Embryo/Somatic Cell Co-culture

1994 The American Association of Bioanalysts: Embryology and Andrology Review Course, Chicago, IL
Title: Embryo culture, assessment and transfer

1994 The American Fertility Society Postgraduate Course: Assisted Reproduction Laboratory Accreditation, San Antonio, TX
Title: Experiences of a Reproductive Laboratory AFS/CAP Inspectee

1995 The American Association of Bioanalysts: State of the A.R.T. Andrology/Embryology Workshop, St. Louis, MO
Title: Oocyte and Embryo Classification and Assessment: Can We Objectively Use Morphological Criteria?

1995 The National Institutes of Health Reproductive Sciences Branch Conference: Endometriosis 2000, Washington DC
Title: Pathophysiology and diagnosis of endometriosis - Biochemical clues

1995 The American Society for Reproductive Medicine Workshop: Strategies for Developing Multicenter Trials for Assisted Reproductive Technologies, Seattle, WA, Co-chairperson and speaker.
Title: Oocyte/Pre-embryo Viability and ART Outcomes

1996 The Society for Gynecologic Investigation Postgraduate Course: Current concepts of endometrial biology, blastocyst interaction and trophoblast invasion in implantation: in vivo biology and in vitro models for research, Philadelphia, PA, Course Director and Speaker.
Title: Pros and Cons of Experimentation Using In Vitro Models

1996 The American Society for Reproductive Medicine Round Table Discussant, Boston, MA
Title: Serum markers for endometriosis

1997 The American Society for Reproductive Medicine Round Table Discussant, Cincinnati, OH
Title: Basic Research in Endometriosis: What we know and where we need to focus

1997 The American Society for Reproductive Medicine Postgraduate Course: Endometriosis: a View from Bench to Bedside, Cincinnati, OH
Title: The Diagnosis of Endometriosis: New Horizons
Title: Endometriosis-Derived Cells: What Can We Learn In Vitro?

1998 The VI World Congress on Endometriosis, Quebec City, Quebec, Canada
Title: Benefits of Modeling for Endometriosis Research

1998 The VI World Congress on Endometriosis, Quebec City, Quebec, Canada
Title: Endometriotic lesions produce a haptoglobin-like protein

2000 The National Institutes of Health SCCPR Endometriosis Focus Group, Stanford University, Palo Alto, CA
Title: Collaborative efforts to enhance endometriosis research

2000 The Fourth International Conference on Human Fertility and Reproduction: The oocyte, the embryo and the uterus, New York University School of Medicine, NY
Title: Endometrial anomalies in women with endometriosis

2000 The American Society for Reproductive Medicine Workshop: Pathogenesis of Endometriosis: Bench to bedside innovations, San Diego, CA
Title: Endometrial-peritoneal interactions in endometriosis

2001 The National Institutes of Health SCCPR Endometriosis Focus Group, Washington DC
Title: Collaborative efforts to enhance endometriosis research

2001 The National Institutes of Health Reproductive Sciences Branch Conference: Endometriosis 2001, Washington DC
Title: Aberrant expression of matrix metalloproteinase enzymes and their inhibitors in endometriosis

2001 The National Institutes of Health Reproductive Sciences Branch Conference: Endometriosis 2001, Washington DC
Title: Rat models for studying endometriosis

2002 The VIII World Congress on Endometriosis, San Diego, CA
Title: The role of matrix metalloproteinase enzymes in the establishment of endometriosis

2003 The American Society for Reproductive Medicine Postgraduate Course: Endometriosis: A critical appraisal, New Orleans, LA
Title: The Origins of Endometriosis: A Basic Scientist’s Perspective

2004 The 39th Midwest Regional Meeting of the Association for Laboratory Animal Science, Columbia, MO
Title: Using rats as a model for the study of endometriosis

2005 The American Society for Reproductive Medicine Interactive Course:
National Institutes of Health Session:
New Findings in Endometriosis Research
Title: Mechanisms Modulating Immune Surveillance in Endometriosis

2011 The Society for Gynecologic Investigation Annual Meeting
Minisymposium:
Rodent and Nonhuman Primate Models in Reproduction: Pros and Cons.
Title: Rats: gRATifying models for human reproduction

Grand Rounds Presentations

1990 The Harvard School of Medicine Fertility and Endocrine Unit Grand Rounds, Brigham and Women's Hospital, Boston, MA
Title: New Concepts in Endometriosis

1990 The University of Missouri School of Medicine, Department of Urology Grand Rounds, Columbia, MO
Title: In Vitro Fertilization Techniques

1991 The University of Missouri School of Medicine, Department of Obstetrics and Gynecology Grand Rounds, Columbia, MO
Title: Basic Pathophysiology of Endometriosis

1992 The University of Missouri School of Medicine Department of Obstetrics and Gynecology Grand Rounds, Columbia, MO
Title: Co-culture: A Method to Enhance Embryo Development in Assisted Reproduction

1993 The University of Missouri School of Medicine Department of Obstetrics and Gynecology Grand Rounds, Columbia, MO
Title: Research Techniques and Methodologies Update

1993 The University of Missouri School of Medicine Department of Obstetrics and Gynecology Grand Rounds, Columbia, MO
Title: Conception, Implantation and Early Embryogenesis

1996 The University of Missouri School of Medicine Department of Obstetrics and Gynecology Grand Rounds, Columbia, MO
Title: Matrix Metalloproteinases and their inhibitors: potential roles in embryo implantation and endometriosis

1996 The University of Missouri School of Medicine Department of Obstetrics and Gynecology Grand Rounds, Columbia, MO
Title: How does pre-surgical GnRH analogue therapy reduce peritoneal adhesion formation?

1997 Wayne State University Department of Obstetrics and Gynecology Grand Rounds, Detroit, MI
Title: Endometriosis: Clinical Applications from Biochemical Clues

1998 The University of Missouri School of Medicine Division of Urology, Grand Rounds, Columbia, MO
Title: Assisted Reproduction Technologies

2000 New York University Department of Obstetrics and Gynecology Grand Rounds, New York, NY
Title: Novel mechanisms in the pathogenesis of endometriosis

2001 The University of Missouri School of Medicine Department of Obstetrics and Gynecology Grand Rounds, Columbia, MO
Title: Endometrial anomalies in women with endometriosis

2002 The University of Missouri School of Medicine Department of Obstetrics and Gynecology Grand Rounds, Columbia, MO
Title: Novel haptoglobin gene expression in the endometrium: insights into endometrial anomalies

2003 The University of Nebraska Medical Center Grand Rounds
Title: Endometrial anomalies in women with endometriosis: from bench to bedside

2005 The University of Missouri School of Medicine Department of Obstetrics, Gynecology and Women’s Health Grand Rounds, Columbia, MO
Title: Diagnosis endometriosis – Is histologic confirmation necessary?

2005 Northwestern University Department of Obstetrics and Gynecology Grand Rounds, Chicago, IL
Title: Mechanisms Modulating Immune Surveillance in Endometriosis

2006 The University of Missouri School of Medicine Department of Obstetrics, Gynecology and Women’s Health Grand Rounds, Columbia, MO
Title: State of the A.R.T. – Update on Assisted Reproduction Technologies

2008 The University of Missouri School of Medicine Department of Obstetrics, Gynecology and Women’s Health Grand Rounds, Columbia, MO
Title: Endometriosis: Genetic or Epigenetic Disease?

2008 The University of Missouri School of Medicine Department of Obstetrics, Gynecology and Women’s Health Grand Rounds, Columbia, MO
Title: Pre-implantation Genetic Diagnosis.

2009 The University of Missouri School of Medicine Department of Obstetrics, Gynecology and Women’s Health Grand Rounds, Columbia, MO
Title: Endometrial Anomalies in Endometriosis: Bench to Bedside.

2010 The University of Missouri School of Medicine Department of Obstetrics, Gynecology and Women’s Health Grand Rounds, Columbia, MO
Title: Embryology and Developmental Anomalies of the Female Reproductive Tract

University Forum and Department Seminar Series Presentations

1987 The University of Kentucky Forum for Reproductive Science, Lexington
Title: Collagen Metabolism in the Retained Bovine Placenta

1988 The University of Kentucky Forum for Reproductive Science, Lexington
Title: Two‑Dimensional Electrophoresis ‑ Techniques and Applications

1988 The University of Kentucky Forum for Reproductive Science, Lexington
Title: Detection of a Unique Secretory Protein in Rats with Surgically-Induced Endometriosis

1989 The University of Kentucky Department of Veterinary Sciences Select Seminars, Lexington, KY
Title: Endometriosis: Potential GnRH Antagonist Therapy

1990 The University of Missouri School of Medicine, Department of Anatomy and Neurobiology, Columbia, MO
Title: Steroid Regulation of Endometrial Proteins

1990 The University of Missouri School of Law, Columbia, MO
Title: Assisted Reproduction-Bioethics

1990 The University of Missouri Animal Science Research Center, Columbia, MO
Title: Endometrial Proteins and Infertility

1991 The University of Missouri School of Medicine Research Council Colloquium, Columbia, MO
Title: Current Concepts in Endometriosis

1991 The University of Missouri Department of Animal Science Reproductive Biology Seminar, Columbia, MO
Title: Embryo and Epithelial Cell Co-culture

1991 The University of Missouri School of Medicine Fifth Annual Obstetrics and Gynecology Update, Columbia, MO
Title: Assisted Reproductive Technology: Laboratory Aspects

1991 The University of Missouri College of Veterinary Medicine Seminars in Biomedical Science, Columbia, MO
Title: A Novel Cell Culture Model for Endometriosis

1992 The University of Missouri School of Medicine Department of Physiology, Columbia, MO
Title: Polypeptides Synthesized and Released by Endometriosis Differ from those of the Uterine Endometrium in Culture

1993 The University of Missouri School of Law, Columbia, MO
Title: Early Fetal Development

1993 The University of Missouri School of Medicine Department of Pharmacology Conferences, Columbia, MO
Title: Endometriosis-associated secretory proteins

1994 The University of Missouri School of Law, Columbia, MO
Title: When does life begin?

1995 The University of Missouri Department of Animal Sciences Reproductive Biology Seminar, Columbia, MO
Title: What are matrix metalloproteinases and their inhibitors doing in the endometrium and endometriosis?

1996 The University of Kansas School of Medicine Women's Research Institute, Wichita, KA
Title: Endometrial and endometriosis secretory proteins: Functional significance and diagnostic Potential

1998 The University of Missouri School of Medicine Department of Molecular Microbiology and Immunology, Columbia, MO
Title: Human Subjects- Responsible Conduct of Research

1998 The University of Missouri School of Law, Columbia, MO
Title: Legal issues of assisted reproduction

2001 The First Annual Missouri Symposium on Women’s Health Research, The University of Missouri-Columbia, Columbia, MO
Title: Endometriosis: From Bench to Bedside

2001 The University of Missouri Combinatorial Biotechnology Group, Columbia, MO
Title: Potential diagnostic and therapeutic significance of endometriosis-associated secretory proteins

2001 The University of Missouri Reproductive Physiology Seminar, Columbia, MO
Title: Progress and Potential for Promotion to Professor

2001 The MO-KAN Workshop, Columbia, MO
Title: Endometrial - peritoneal interactions in the pathogenesis of endometriosis

2004 The University of Missouri School of Medicine Department of Obstetrics and Gynecology Seminar Series
Title: Statistics without Torture

2005 The University of Missouri School of Medicine Department of Obstetrics, Gynecology and Women’s Health
Title: Diagnosing Endometriosis

2008 The University of Missouri Department of Obstetrics, Gynecology and
Women’s Health, Division of Reproductive and Perinatal Research
Title: How NIH Reviewer’s Review Your Grant Application

2009 The University of Missouri School of Medicine Department of Obstetrics, Gynecology and Women’s Health
Title: Update on State of ART: Practice versus Research

2010 The University of Missouri School of Medicine Department of Obstetrics, Gynecology and Women’s Health Seminar Series
Title: Primate Models to Study Reproductive Disease

Pharmaceutical Company Presentations

1989 The UpJohn Seminar Series in Reproductive Endocrinology and Infertility, Lexington, KY
Title: Laboratory Techniques in Infertility Research
1992 Adeza Biomedical Corporation, Sunnyvale, CA
Title: The Biochemical Characteristics of Endometriosis

Community Service Presentations

1981 The National Veterinary Medical Association and the Department of Youth Education, Murfreesboro, TN
Title: Selection and Care of Horses

1983 The Ellington Agricultural Center, Nashville, TN
Title: Equine Reproduction

1984 Special Olympics Program ‑ Rutherford County, Murfreesboro, TN
Title: Instruction Techniques for Coaches of Handicapped Riders

1989 The University of Kentucky Health Careers Opportunity Program for Underserved Minorities, Lexington, KY
Title: Endometriosis: An Experimental Approach

1990 The University of Missouri, Fertility Services Group, Columbia, MO
Title: The In Vitro Fertilization Laboratory

1991 The Mid-Missouri Chapter of the Association of Operating Room Nurses, Columbia, MO
Title: The In Vitro Fertilization Laboratory

1991 The University of Missouri Fertility Services Group, Columbia, MO
Title: Early Embryo Development

1992 The Central Missouri Society for Ultrasonography, Columbia, MO
Title: In Vitro Fertilization and Gamete Intrafallopian Tube Transfer

1993 The University of Missouri Infertility Support Group, Columbia, MO
Title: Behind Closed Doors - Infertility Laboratories

1993 The University of Missouri Physicians Patient Education Conference, Columbia, MO
Title: Waiting, hoping, coping...the infertility experience. The "ART" of IVF/GIFT

1994 The University of Missouri Physicians Patient Education Conference, Columbia, MO
Title: Waiting, hoping, coping...the infertility experience. Behind the scenes look at the IVF laboratory

1995 The University of Missouri Physicians Patient Education Conference, Columbia, MO
Title: Waiting, hoping, coping...the infertility experience. Micromanipulation for assisted oocyte fertilization and embryo implantation

1995 The University of Missouri Ninth Annual Ob/Gyn Update Conference, Columbia, MO
Title: State of the A.R.T.: Intracytoplasmic Sperm Injection and Assisted Hatching

1996 The University of Missouri Physicians Patient Education Conference, Columbia, MO
Title: Waiting, hoping, coping...the infertility experience. What new laboratory techniques can do for you

1999 The University of Missouri Hospital and Clinics Surgery Services, Columbia, MO
Title: New developments in assisted reproductive technologies

2001 Hickman High School Speak Your Mind Forum, Columbia, MO
Title: Issues and Policies of Stem Cell Research

2002 Dalton Science Teacher's Symposium, Columbia, MO
Title: Stem Cells: Research, Potential and Policy

Intramural Activities

Faculty Sponsor

1979 – 1986 MTSU Horseman's Association
1980 – 1986 MTSU Pre‑Veterinary Medical Society

Campus Committees

1980 - 1983 MTSU Campus and Grounds Committee
1982 – 1986 Tennessee State Livestock Pavilion Policy Board
1992 MU Department of Internal Medicine Ad Hoc Grant Reviewer
1995 – 1998 MU Hearnes Center Committee, Co-chairperson 1996-97
1996 – 1998 MU Academic Grievance Gearing Panel
2000 – 2001 MU Search Committee - Director of the Office of Animal Resources
2000 – 2009 MU Office of Research Health Sciences Advisory Committee
1992 – Present MU System Research Board Ad Hoc Grant Reviewer
2005 – Present MU Campus Embryonic Stem Cell Research Oversight (ESCRO) committee

Medical School Committees

1990 – Present MU Fertility Services Advisory Panel
1991 - 1994; 1998 – 2000 MU Research Council
2002 MU Search Committee - Chair for the Department of Neurology 1991 - 1997 MU School of Medicine Faculty Affairs Council
1992 – 1993: Secretary
1994 – 1995: Vice-Chair
1995 – 1996: Chair
1996 – 1997: Interim Chair
1993 MU LCME Re-accreditation Review Committee
1993 – 2001 MU Institutional Review Board - Health Sciences Section 1998 – 2000: Vice Chair
1995 – 1996 MU Search Committee - Chairperson for the Department of Obstetrics and Gynecology
1996 – 1997 MU School of Medicine Alternative Faculty Title Series Committee
1996 – 1998 MU School of Medicine Faculty Salary Committee
2001 MU Molecular Biology Week Poster Judge
2003 – Present MU Administrative Research Council

Departmental Committees

1979 - 1986 MTSU Horse Science Committee
1980 MTSU Search Committee - Public Service/Horse Science, Chair
1991 MU Search Committee - Beef Extension/Nutrition Specialist
1991 – Present MU-ART Program Quality Assurance Committee, Chair
1992 – 1993 MU Search Committee - Food for the 21st Century Asst. Prof.
1993 – 1994 MU Search Committee - Andrology Laboratory Director and Assistant Professor, Co-Chair
1995 MU Search Committee - Beef Extension Specialist
1995 MU Animal Science Development Committee - Tissue bank
1991, 92, 93, 94, 95, 99, 2000 MU Ob/Gyn Resident Selection/Match
1995 - 1998 MU Food for the 21st Century Program - Transgenic Lab Director Search Committee
1995 Ob/Gyn Oncology Faculty Search Committee
1997 – 2008 Ob/Gyn Promotion & Tenure Committee
1998 MU Food for the 21st Century Program - Speakers Committee
1999 - 2008 MU Mission Enhancement Faculty Search Committee, Co-chair
2000 MU FIGO Fellowship Program - Assist in training visit of Suskham Djusad, M.D.
2003 – Present Ob, Gyn & Women’s Health Executive Committee
2003 – 2006 Ob, Gyn & Women’s Health REI Chief Search Committee
2004 – 2009 Ob, Gyn & Women’s Health Division of Reproductive and Perinatal Research Faculty Search Committee, Chair
2004 – Present Ob, Gyn & Women’s Health Generalist Search Committee
2006 – 2007 Ob, Gyn & Women’s Health Gyn Oncologist Search Committee
2007 - Present Ob, Gyn & Women’s Health Urogynecologist Search Committee
2009 - 2010 Ob/Gyn & Women’s Health Promotion & Tenure Committee, Chair

Division Administration

1996 – Present Organize and conduct monthly Research Division Faculty meetings
1991 – Present David G. Hall Symposium – Organizational committee,
2001 – Present Chair
2003 – Present Prepare and Revise/Update State of the Research Division Report
2005 Faculty Search Committees (3 Faculty) – Research Division
2005 – Present Organize and moderate Research Division (all personnel) meetings / training sessions
2005 – Present Conduct annual review for division faculty
2006 - Present Monthly Division Director meetings with Dr. Winn
2006 Create original template and work with Dr. Winn to finalize Department Salary Savings Policy
2006 Create original template and work with Dr. Winn to finalize Department RIF Policy
2006 Create original template and work with Dr. Winn to finalize Department GCI Plan

2007 Recruitment Committee for Grants and Contracts Specialist - Chair
2007 Organize and moderate Research Division Retreat
2008 Organize and moderate Research Division Retreat
2009 Participate in Research Division Retreat

Intramural Training

1900 – Present MU Institutional Review Board Training - Health Sciences Section
1990, 1993, 1996, 1999
Department of Health Physics: Radiation Safety and Hazardous Waste Management
1991, 1992, 1994
Promotion and Tenure Workshop
1991 The College of Veterinary Medicine: Certification Symposium on Humane Animal Care and Use
1993 University Hospital and Clinics Safety Training
1996 Hazardous Materials Management
1998 Humane Care and Use of Animals in Research and Teaching
2000 Health Physics Workshop on Radiation Safety Web Site Manual
2001 Women’s Health Vision Retreat
2001 Real Time Polymerase Chair Reaction
2006 Environmental Health and Safety – Chemical Worker Training
2006 Applied Bioscience Real Time PCR Training
2007 Environmental Health and Safety – Biosafety Training
2010 Environmental Health and Safety – Biosafety Training

Extramural Activities

National Institutes of Health Study Section Member

1996 NIH P50 Center Site Visit Team Member
1998 NICHD U54 SCCPRR Center Site Visit Team Member
1998 NICHD Special Emphasis Program Project Team Member
2000 NICHD U54 SCCPRR Center Review Panel Member
2001 NICHD ZRG1 HED-1 Special Emphasis Review Panel Member
2003 - 2004 NICHD REN Study Section Member
2004 - 2007 NICHD ICER Study Section Member
2009 NIH RC1 Challenge Award Reviewer
2010 NIH ICER Study Section Ad hoc member
2010 NIH NICHD Special Emphasis Panel ZRG1 EMNR E(50) Member

Ad hoc External Grant Reviewer

1990 The Grayson‑Jockey Club Research Foundation, Lexington, KY
1994 - 1996 U.S. Environmental Protection Agency, Research Triangle Park, NC
1995 North Carolina Biotechnology Center, Research Triangle Park, NC
1995 United States AMRMC, Ft. Detrick, MD
1996 NIH P50 Center Site Visit Team Member
1997 National Science Foundation, Arlington, VA
1998 NIH U54 SCCPRR Center Site Visit Team Member
1998 NICHD Special Emphasis Program Project Team Member
1999 University of Leuven, Leuven, Belgium
2000 NICHD U54 SCCPRR Center Review Panel Member
2001 NIH ZRG1 HED-1 Special Emphasis Review Panel Member
2009 NIH RC1 Stimulus Money Challenge Award Reviewer
2010 NICHD ICER Ad hoc Study Section Member
2010 NIH NICHD Special Emphasis Panel ZRG1 EMNR E(50)

Associate Editor

2003 – 2006 Human Reproduction
2007 – Present Human Reproduction Update

Ad hoc Journal Reviewer (review ~50 manuscripts per year)

1989 – Present Biology of Reproduction
1994 – Present American Journal of Obstetrics and Gynecology
1994 Society for Experimental Biology and Medicine
1995 – 2000 TIME Life Medical Board, TIME Warner Inc. Ed: C. Everett Koop
1996 – Present Journal of Clinical Endocrinology and Metabolism
1996 – Present Molecular and Cellular Endocrinology
1996 - Present Fertility and Sterility
1998 – Present Reproductive Sciences (formerly J Soc Gynecol Invest)
1998 – Present Human Reproduction
1999 - Present Molecular Human Reproduction
1999 – Present Human Reproduction Update
1999 – Present Journal of Clinical Endocrinology and Metabolism
2000 – Present American Journal of Reproductive Immunology
2000 – Present Reproduction (formerly J Reprod Fertility & Reviews in Reprod)
2002 - Present Gynecologic and Obstetric Investigation
2002 – Present Trends in Molecular Medicine
2004 – Present Toxicological Sciences
2004 – Present Cellular and Molecular Life Sciences
2006 – Present Clinical Chemistry and Laboratory Medicine
2006 – Present Journal of Endocrinology
2009 – Present European Journal of Obstetrics & Gynecology
& Reproductive Biology
2009 – Present Journal of Proteome Research
2009 – Present Cell & Tissue Research
2010 – Present The Journal of Obstetrics and Gynaecology Research

Examination Construction Team

1995, 1996 American Board of Bioanalysts
High Complexity Clinical Laboratory Director Certification
General Laboratory, Embryology and Andrology Subspecialties

Accreditation Site Visits

1995, 1996, 1997, 1998, 2003, 2006, 2008, 2010
College of American Pathologists (CAP) Reproductive Laboratory
Accreditation Program

Member

1980 - 1986 Intercollegiate Horse Show Association
1980 – 1986: National Board of Directors
1980 – 1986: President of Region VI
1979 – 1986 Collegiate Coach Middle Tennessee State University
1979 – 1986 Hunter and Stock Seat Equestrian Teams
1979 – 1981: Intercollegiate Horse Judging Team
1987 – 1990 University of Kentucky Forum for Reproductive Sciences
1990 – Present Food for the 21st Century Animal Reproductive Biology Group
1990–94; 2001 – Present
The Endometriosis Association
2008 – Present: Scientific Review Board (appointed)
1990 – Present American Association for the Advancement of Science
1989 – Present American Society for Reproductive Medicine (ASRM; formerly AFS) 1996, 1997, 1998: Invited Roundtable Speaker
1998: General Program Abstract/Prize Paper Committee
2001: Endometriosis Abstract Committee
2003: Postgraduate Course Faculty (invited)
2005: NIH Interactive Session Speaker (invited)
2005: Endometriosis Abstract Committee
2006: Endometriosis Abstract Committee
2009: Endometriosis Abstract committee (Chair)
2009: ASRM Strategic Planning Committee (Invited)

1990 – Present Reproductive Biology Professional Group
1992 – 1995 Nominating Committee (elected position)
1993 – 1994: Vice-chair
1994 – 1995: Chair
1992 – 1994: Research Development Committee
1995, 1996: Program Committee
1996, 1997, 1998, 2002: Abstract Review Committee
(1998 Chairperson)
1999 – 2003: Distinguished Scientist Award Committee
2007 – Present Endometriosis Special Interest Group
2007: Develop group with Drs. Rob Taylor and Dan Lebovic
2007: Vice Chair – elected position
2008: Chair
2009: Immediate Past Chair
1992 – Present Society for Assisted Reproductive Technology (SART)
1994 – 1996: Director on SART Executive Council (elected)
1999, 2003, 2006: Abstract Review Committee
1987 – Present Society for the Study of Reproduction
1988 – 1990: Membership Committee
1995: Faculty-Trainee Luncheon
1996 – 1998: Publication Committee
1990 – Present The Association of Professor's of Gynecology and Obstetrics
1994 – Present Society for Gynecologic Investigation (elected to membership)
1996: Postgraduate Course Chairperson (invited)
1996 - Present: Abstract Review Committee - annually
1999 – Present American Association of Bioanalysts
2004, 2006, 2007, 2010
European Society for Human Reproduction (ESHRE)
Abstract Review Committee Member (Invited)

Teaching Experience:

Lecture and Laboratory Courses

1976-77 Graduate Teaching/Research Assistant - Southern Illinois University - Carbondale
Animal Industries Department

  • Laboratory Instructor:
    Agriculture 220: Horsemanship and Equitation (3 credit hours)
    Agriculture 319: Horses and Horsemanship (3 credit hours)
    Agriculture 419: Stable Management (3 credit hours)

1979-1985: Instructor

1985-1986: Assistant Professor - Middle Tennessee State University - Murfreesboro
Department of Animal/Equine Sciences

  • Courses Taught:
    Animal Science 211: Beginning Horsemanship (2 credit hours)
    Animal Science 340: Intermediate Horsemanship (3 credit hours)
    Animal Science 440: Advanced Horsemanship (3 credit hours)
    Animal Science 304: Stable Management (3 credit hours)
    Animal Science 345: Anatomy & Physiology of Domestic Animals (3 crdt hours)
    Animal Science 445: Techniques of Teaching Horsemanship (3 credit hours)
    Animal Science 491: Research Problems in Agriculture (1-3 credit hours)
  • Undergraduate Academic Advisement:
    Pre‑Veterinary Medicine
    Animal & Equine Sciences

1987-1990: Postdoctoral Fellow in Reproductive Endocrinology - University of Kentucky Medical Center – Lexington
Department of Obstetrics and Gynecology, School of Medicine

  • Co‑instructor:
    Physiology 502: Endocrinology
    • Specific Lectures:
      Female Reproductive Endocrinology
      Male Reproductive Endocrinology
      Endocrinology of Pregnancy and Lactation
    Physiology 811: Principles of Physiology
    • Obstetrics and Gynecology Resident Physician Conferences
      Endometrial Physiology
      New Technologies in Reproductive Medicine

1990-1996: Assistant Professor
1996-2002: Associate Professor with Tenure
2002-Present: Professor University of Missouri - Columbia

  • Department of Obstetrics and Gynecology
    Department of Animal Science
    Comparative Medicine Program

University of Missouri – Columbia: Basic and Translational Science

Years Postdoctoral Fellow Mentor Current Position
1993 – 1995 Jean Wright, D.V.M. Sr. Research Vet., Eli Lilly, Indiana
1994 - 1996 Yuanjue Zhang, Ph.D. Physician, private practice in Oklahoma
1996 – 1998 Marta Piva, Ph.D. Assist Prof, Alcorn State Univ., MS
2004 – 2006 Renita Marshall, D.V.M. Assist Prof, Southern Univ., LA

 

Years Doctoral Faculty Committee Status
1990 – 1993 Steven Terlouw Ph.D. degree awarded 1993 (M. Smith lab)
1995 – 1998 Susan Nagel Ph.D. degree awarded 1998 (F. vom Saal lab)
1996 – 2000 William Rickie Ph.D. degree awarded 2000 (M. Smith lab)
1995 – 2000 Melissa Larson Ph.D. degree awarded 2001 (R.M. Roberts lab)
1996 – 2001 Katie Cox* Ph.D. degree awarded 2001
2000 - 2002 Kristin Sieren Accepted position in industry 2002
2002 – 2007 Jennifer Luth* Ph.D. degree awarded 2007
2008 - Present Julie Weaver-Stilley* Ph.D. candidate
2009 - Present Lana Bruney Ph.D. candidate (M.S. Stack Lab)

*Dissertation supervisor

Years Graduate Faculty Committee Status
1990 – 1992 Rick Schonbach M.S. degree awarded 1992 (M. Smith lab)
1990 – 1998 Randall Zimmer
M.S. degree awarded 1998 (W. Loch lab)
1993 – 1994 Eric Kayl Deceased
1994 Mario Mayes M.S. Candidate 1993
1993 – 1997 Wendy Jolliff M.S. degree awarded 1997 (R. Prather lab)
2000 – 2002 Jennifer Luth M.S. degree awarded 2002 (R. Prather lab)
2006 – 2008 Julie Weaver-Stilley* M.S. degree awarded 2008
2008 – Present Julie Birt* M.S. candidate 2010
2008 – Present Rong Jiang M.S. candidate 2010(S. Stack Lab)
2009 – Present Mamum Almanun M.S. candidate (R. Rivera Lab)
2010 – Present Emma Jinx M.S.candidate (Michael F. Smith lab)

*Thesis supervisor

Other Graduate Education

1997: Physiology 401 Female and Male Reproduction (4 lectures, 2 labs)
1998: Molecular Microbiology and Immunology 411 (1 lecture)
2001: Animal Science 301/400 Special topics in Transgenics Technology (1 lecture)
2009: Sinclair School of Nursing Preceptor. Denise Clark, RN. Nursing in an ART Clinical and Laboratory Setting

Undergraduate Education

1998 Bidisha Ray, Sequential embryo culture media for IVF
1999 Bidisha Ray, MMP-integrin interaction in endometrium
2006 - 2007 Lilian Lwin, Haptoglobin alters macrophage function
2006 - 2008 Julie Van Hook-Birt, Analysis of haptoglobin gene expression in endometriosis by real time PCR
2009 - Present Emily Rigden, Uterine vascular factors in rats with surgically-induced endometriosis
2009 – Present Dana Brown Protease inhibitor activity in peritoneal fluid

High School Student Research Apprentice Program Preceptor

1994 Nakita Mapp, Assisted Reproduction
2004 – 2006 Kenneth Tan, Gene analyses in endometriosis
2004 – 2006 Esther Lee, MMPs in immortalized stromal cells
2004 – 2006 Lilian Lwin, Macrophage cytokines

University of Missouri – Columbia: School of Medicine

Visiting Scholar

1992 Volker Vierick University of Ulm, ULM, Germany

Resident Physician Didactic Courses (starting 1990)

Morphological and functional development of the fetus
Conception, placentation and fetal membranes
Embryology and congenital anomalies of the genital tract
Medical statistics
Critically reviewing medical literature
The origins of endometriosis – consider the source for novel treatment approaches
Pre-implantation Genetic Diagnosis (PGD)

Ob/Gyn Resident Research Mentor

1992 Patrick Bruno, M.D. IGF binding proteins in endometriosis
1993 Patrick Bruno, M.D. GM-CSF in endometriosis
1994 Gina Muscolino, M.D. PUP-1 in human placenta
1995 Lydia Keisler, M.D. TIMP-1 in peritoneal fluid
1995 Gina Muscolino, M.D. ENDO-2 in uterus vs. endometriosis
1996 Lydia Keisler, M.D. Effects of GnRHa on TIMP-1 in endometriosis
1997 Lydia Keisler, M.D. Altered PA/MMP in endometriosis
1997 Bret Penney, M.D. Cell adhesion molecules in endometriosis
1997 Bret Barrier, M.D. Aberrant integrin expression in reproduction
1997 Joel Mauer, M.D. Freshman reproductive health survey
1997 Beth Helgerson, M.D Breast cancer statistics: stage at presentation
1998 Chris Litherland. M.D. The role of haptoglobin in endometriosis
1998 Bret Barrier, M.D. Immune dysfunction in endometriosis
2000 Joel Mauer, M.D. Reproductive health survey of college seniors
2000 Bret Barrier, M.D The role of the peritoneum in endometriosis
2001 Amy Mitheun, M.D Effects of the new GnRH antagonist, Antagon, on oocyte and embryo quality, endometrial development, implantation, and pregnancy
2002 Amy Mithuen, M.D. Cervical Cancer Treatment Complications
2004-05 Shannon Forsetter, M.D. Endometrial MMPs during the window of implantation in women with endometriosis
2005 Mistie Piel, M.D. Labor induction protocol and the use of Misoprostol: analysis of dose variability
2006 Laura Laue, M.D. Immune changes in endometriosis
2006 Erin Tuller, M.D. Haptoglobin in endometrial adenocarcinoma

Ob/Gyn Fourth Year Advanced Biomedical Sciences Research Elective

1991 Marsha Fisher Embryogenesis through the 4-cell block
1997 Christina Litherland Serum diagnostics for endometriosis
1998 Joseph Sirintrapun Serum haptoglobin in endometriosis
2000 - 2001 Kristen Costello Endometriotic haptoglobin on angiogenesis
2002 - 2003 Bridget Rutledge Haptoglobin in endometrial cancer
2004 - 2005 Christine Shank HLAG in human endometrium
2009 – 2010 Kara Ehlers E2 concentrations and activity in peritoneal fluid in endometriosis

Third Year Obstetrics and Gynecology Clerkship

1990 – 1997 Endometrial anomalies
1990 – Present Endometriosis
1990 – 2001 Endocrinology of pregnancy
1990 – Present Dysfunctional uterine bleeding
2003 – 2006 Early Embryology

Summer Research Fellowship for Medical Students

1991 Rifat Khan, M4 Cell culture model for endometriosis
1991 Doxaben Patel, M1 PUP-1 in early pregnancy
1992 Doxaben Patel, M2 PUP-1 in early pregnancy
1992 Roshni Shukla, Conley Embryo coculture with endometriosis
1993 Kristen Kasper, M2 GM-CSF in endometriosis
1993 Shannon Trammell, M2 GM-CSF in endometriosis
1994 Pat Gilbreth, M2 Decidual cell production of PUP-1
1994 Sommer Sirawan, M2 Embryo cryopreservation during the cell cycle
1994 Christina Litherland, M2 Peritoneal fluid proteins (1st Place Award in Medical Student Competition)
1996 Dawn Robinett, M1 Effect of steroids on PUP-1 mRNA expression
1996 Katy Walton, Conley Effect of steroids on PUP-1 protein expression
1997 Amanda Heinsz, UG Haptoglobin: a serum marker for endometriosis
2000 Donna Senciboy, UG Progesterone effects on cervical characteristics
2001 Donna Senciboy, UG Effects of GnRH analogues on IVF outcomes
2001 Jamie Joyce, M2 Effects of GnRH analogues on IVF outcomes
2008 Manessha Sabharwal, M2 Spontaneous pregnancy loss in females with endometriosis: initiation and cause?

First Year Problem Based Learning (PBL) Lecturer

1995 - Present: Block 4 Oogenesis, fertilization, embryo development & implantation
1997 – 1998: Block 3 Organizing Committee - Neuroendocrinology
2005 – Present: Embryology I
2007 – Present: Embryology II

Hickman High School Science Initiative

2003-04 Kenny Tan Haptoglobin in endometrial cancer
2003-04 Lillian Lwin Effects of haptoglobin on macrophage function
2003-04 Esther Lee Telomerase immortalized endometrial cells

Clinical Assisted Reproduction Experience:

1987 - 1990 Associate Laboratory Coordinator/Embryologist
Assisted Reproductive Technologies/RIA Laboratories
University of Kentucky Medical Center, Lexington

1990 - Present Director and Embryologist Assisted Reproduction Laboratories
Missouri Center for Reproductive Medicine and Fertility
Department of Ob, Gyn and Women’s Health
University of Missouri, Columbia