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Division of Animal Sciences
College Of Agriculture, Foods, and Natural Resources
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Animal Science Faculty

Peter Sutovsky
Curriculum Vitae

Peter Sutovsky

Associate Professor

Reproductive Physiology


S134D Animal Science Research Center
Division Of Animal Sciences
Columbia, MO 65211

Publications

  1. Tengowski MW, Feng D, Sutovsky M, Sutovsky P (2006) Differential expression of genes encoding constitutive and inducible 20S proteasomal core subunits in the testis and epididymis of theophylline- or 1,3-dinitrobenzene-exposed rats. Biol. Reprod. In press
  2. Lovercamp KW, Safranski TJ, Fischer KA, Manandhar G, Sutovsky M, Herring W, Sutovsky P (2006) Arachidonate 15-lipoxygenase and ubiquitin as fertility markers in boars. Theriogenology, In press
  3. Sutovsky P, Plummer W, Baska K, Peterman K, Diehl JR, Sutovsky M (2006) Relative Levels of Semen Platelet Activating Factor-Receptor (PAFr) and Ubiquitin in Yearling Bulls with High Content of Semen White Blood Cells: Implications for Breeding Soundness Evaluation. J. Androl., In press.
  4. Katayama, M., Zhong, Z., Lai, L., Sutovsky, P., Prather, R.S., Schatten, H. (2006). Mitochondrial distribution and microtubule organization in fertilized and cloned porcine embryos: Implications for developmental potential. Dev. Biol., In press.
  5. Manandhar G, Feng D, Yi Y-J, Lai L, Letko J, Laurincik J, Sutovsky M, Salisbury JL, Prather RS, Schatten H & Sutovsky P (2006) Centrosomal Protein Centrin is not Detectable during Early Pre-implantation Development but Reappears during Late Blastocyst Stage in Porcine Embryos. Reproduction, In press.
  6. Yi Y-J, Manandhar G, Oko RJ, Breed WG, and Sutovsky P. (2006) Mechanism of Sperm-Zona Pellucida Penetration during Mammalian Fertilization: 26S Proteasome as a Candidate Egg Coat Lysin. Reproduction/Supplement, In press.
  7. Yu Y., Xu W., Yi Y-J, Sutovsky P., Oko R. (2006) The extracellular protein coat of the inner acrosomal membrane is involved in zona pellucida binding and penetration during fertilization: Characterization of its most prominent polypeptide (IAM38). Dev. Biol., 290:32-43.
  8. Hao, Y., L. Lai, G.-S. Im, Z. Liu, D. Wax, M. Samuel, C.N. Murphy, P. Sutovsky, R.S. Prather. 2006. Developmental competence of porcine parthenogenetic embryos relative to embryonic chromosomal abnormalities. Mol. Reprod. Dev. 73:77-82.
  9. Katayama M, Sutovsky P, Yang BS, Cantley T, Rieke A, Farwell R, Oko R & Day BN (2005) Increased disruption of sperm plasma membrane at sperm immobilization promotes dissociation of perinuclear theca from sperm chromatin after intracytoplasmic sperm injection in pigs. Reproduction, 130: 907-916.
  10. Fischer KA, Van Leyen K, Lovercamp KW, Manandhar G, Sutovsky M, Feng D, Safranski T & Sutovsky P (2005) 15-Lipoxygenase (15-LOX) is a component of sperm cytoplasmic droplet. Reproduction, 130:213-222.
  11. Sutovsky P, Manandhar G (2006) Mammalian Spermatogenesis and Sperm Structure: Anatomical and Compartmental Analysis. In: The Sperm Cell: Production, Maturation, Fertilization,Regeneration. DeJonge C, Ed., Cambridge University Press, Cambridge, UK, In Press; available April 2006.
  12. Ozanon C, Chouteau J, and Sutovsky P (2005) Clinical adaptation of the ubiquitin based sperm quality assay (SUTI): Relationship of sperm ubiquitination with sperm quality in gradient-purified semen samples from 93 men from a general infertility clinic population. Human Reprod., 20(8):2271-2278.
  13. Manandhar G, Sutovsky P (2006). Comparative Histology and Subcellular Structure of Mammalian Spermatogenesis and Spermatozoa. In: Comparative Reproductive Biology. Schatten H, Ed., Iowa State Press, A Blackwell Publishing Company. In press.
  14. Sutovsky P, Manandhar G,Laurincik J, Letko J, Caamano JN, Day BN, Lai L, Prather RS,Sharpe-Timms KL, Zimmer R, and Sutovsky M. (2005) Expression and proteasomal degradation of the major vault protein (MVP) in mammalian oocytes and zygotes. Reproduction 129:269-279.
  15. Manandhar D, Schatten H, Sutovsky P (2005). Centrosome reduction during gametogenesis and its significance. Biol Reprod. 72: 2-13.
  16. Baska KM Sutovsky P, (2005) Protein modification by ubiquitination and is consequences for spermatogenesis, sperm maturation, fertilization and pre-implantation embryonic development. In: New impact on protein modifications in the regulation of reproductive system. Tokumoto, T, Ed., Research Signpost, Kerala; 83-114.
  17. Tengowski M.W., Sutovsky P., Hedlund L.W., Guyot D.J., Burkhardt J.E., Thompson W. E., Sutovsky M., and Johnson G.A. (2005). Reproductive cytotoxicity is predicted by magnetic resonance microscopy and confirmed by ubiquitin-proteasome immunohistochemistry in a theophylline-induced model of rat testicular and epididymal toxicity. Microsc. & Microanalysis., 11:1-13.
  18. Prather RS, Sutovsky P and Green JA. (2004) Nuclear remodeling and reprogramming in transgenic pig production. Exp. Biol. Med., 229: 1120-1126.
  19. Sutovsky, P., Manandhar G., McCauley, T.C., Caamaño JN, Sutovsky, M., Thompson WE, and Day, B.N. (2004). Proteasomal interference prevents zona pellucida penetration and fertilization in mammals: Biol Reprod., 71, 1625–1637
  20. JiménezA, Zu W, Rawe VY, Pelto-Huikko M, Flickinger CJ, Sutovsky P, Gustafsson J-A, Oko R and Antonio Miranda-Vizuete A. (2004) Spermatocyte/spermatid-specific thioredoxin-3, a novel Golgi apparatus-associated thioredoxin, is a specific marker of aberrant spermatogenesis. J. Biol. Chem. 279(33):34971-34982.
  21. Tovich PR, Sutovsky P and Oko RJ (2004) Novel aspect of perinuclear theca assembly revealed by immunolocalization of non-nuclear somatic histones during bovine spermiogenesis. Biol. Reprod., 71(4):1182-94.
  22. Thompson WE, Asselin E, Branch A, K. Stiles JK, Sutovsky P, Lai L, Im G-S, Prather RS, Isom SC, Rucker III E and Tsang BK (2004) Regulation of prohibitin expression during follicular development and atresia in the mammalian ovary. Biol. Reprod., 71(1):282-290.
  23. Sutovsky P, Prather RS (2004) Nuclear remodeling after SCNT: A contractor’s nightmare. Trends Biotech., 22(5):205-8
  24. Sutovsky P, Hauser R, Sutovsky M (2004) Increased levels of sperm ubiquitin correlate with semen quality in men from an andrology laboratory clinic population. Human Reprod. 19:1-11.
  25. Miranda-Vizuete A, Tsang K, Yu Y, Alberto Jiménez A, Pelto-Huikko M, Flickinger CJ, Sutovsky P, and Oko R (2003). Cloning and developmental analysis of murid spermatid-specific thioredoxin-2 (Sptrx-2), a novel sperm fibrous sheath protein and autoantigen. J Biol Chem., 278:44874-44885.
  26. Miranda-Vizuete A, Sadek CM, Jiménez A, Krause WJ, Sutovsky P and Oko R (2004) The mammalian testis-specific thioredoxin system. Antioxid Redox Signal. 6:25-40
  27. Sutovsky P, van Leyen K, McCauley T, Day BN, and Sutovsky M (2004). Degradation of the paternal mitochondria after fertilization: Implications for heteroplasmy, ART and mtDNA inheritance. Reprod. Biomed. Online 8, 24-33.
  28. Thompson WE, Ramalho-Santo J, and Sutovsky P (2003). Ubiquitination of prohibitin in mammalian sperm mitochondria: Possible roles in the regulation of mitochondrial inheritance and sperm quality control. Biol. Reprod., 69:254-260
  29. Sutovsky, P., Manandhar, G., Wu, A., and Oko, R. (2003) Interactions of the sperm perinuclear theca with the oocyte: Implications for oocyte activation, anti-polyspermy defense and assisted reproduction. Microsc. Res. Tech., 61:362-378. (Invited Article).
  30. Sutovsky, P., McCauley, T.C., Sutovsky, M., and Day, B.N. (2003). Early degradation of paternal mitochondria in domestic pig (Sus scrofa) is prevented by selective proteasomal inhibitors lactacystin and MG 132. Biol. Reprod., 68:1793-1800.
  31. Sutovsky P. 2003. Ubiquitin-dependent proteolysis in mammalian spermatogenesis, fertilization, and sperm quality control: killing three birds with one stone. Micros. Res. Tech., 61: 88-102 (Invited contribution)
  32. Sutovsky P. (2004) Visualization of sperm accessory structures in the mammalian spermatids, spermatozoa and zygotes In : Methods In Molecular Biology, vol 253: Germ Cell Protocols: Vol. 1Sperm and Oocyte Analysis. (Heide Schatten, Editor), Human Press, Totowa, NJ pp. 59-77.
  33. Rawe, V.Y. , Brugo Olmedo, S., Nodar, F.N., Ponzio, R., Sutovsky, P. (2003) Abnormal assembly of annulate lamellae and nuclear pore complexes coincides with fertilization arrest at pronuclear stage of human zygotic development. Human Reprod., 18, 576-582.
  34. Sutovsky P, Turner RM, Hameed S, Sutovsky M (2003) Differential ubiquitination of stallion sperm proteins: Possible implications for infertility and reproductive seasonality. Biol. Reprod., 68, 688-698
  35. Rawe, V.Y., Brugo Olmedo, S., Benmusa, A.,Shiigi, S. M., Chemes, H.E., and Sutovsky, P. 2002. Sperm Ubiquitination in Patients with Dysplasia of the Fibrous Sheath. Human Reprod., 17:2119-2127.
  36. Sutovsky, P., Neuber, E., and Schatten, G. (2002). Ubiquitin-Dependent, Sperm Quality Control Mechanism Recognizes Spermatozoa with DNA Defects, as Revealed by Dual Ubiquitin-TUNEL Assay. Mol. Reprod. Dev., 61: 406-413.
  37. Sutovsky, P., Motlik, J., Neuber, E., Pavlok, A., et al., (2001) Accumulation of the proteolytic marker peptide ubiqutin in the trophoblast of mammalian blastocysts. Cloning & Stem Cells 3, 157-161.
  38. Oko R, Aul R, Wu A, Sutovsky P. 2001. The sperm head skeleton. In: Andrology in the 21st century. Robaire B, Chemes H, Morales CR, Editors. Medimond Publishing Co., Englewood NJ,pp.37-51
  39. Sutovsky, P., Moreno, R., Ramalho-Santos, J., Dominko, T., Thompson, W. E., and Schatten, G. (2001). A Putative, Ubiquitin-Dependent Mechanism for The Recognition and Elimination of Defective Spermatozoa in the Mammalian Epididymis. J. Cell Sci. 114, 1665-1675
  40. Sutovsky, P., Terada, Y., and Schatten, G. (2001) Ubiquitin-based sperm assay for the diagnosis of male factor infertility. Human Reprod. , 16, 250-258
  41. Sutovsky, P.*, et al., cited as Ramalho-Santos, J.*, Sutovsky, P.*, Simerly, C., Oko, R., Wessel, G., Hewitson, L., and Schatten, G. (2000) ICSI choreography: fate of sperm structures after monospermic rhesus ICSI and first cell cycle implications. Human Reprod. 15, 2610-2620; *P.S>. And J. R.-S. contributed equally to this study and are thus acknowledged as “first co-authors” in the paper.
  42. Sutovsky, P., Moreno, R., Ramalho-Santos, J., Dominko, T., Simerly, C., and Schatten, G. (2000) Ubiquitinated sperm mitochondria, selective proteolysis and the regulation of mitochondrial inheritance in mammalian embryos. Biol. Reprod. 63, 582-590
  43. Ramalho-Santos J., Moreno, R. D., Sutovsky, P., Chan,A. W.-S., Hewitson, L. C., Wessel, G. M., Simerly, C. R., and Schatten, G. (2000) SNAREs in mammalian sperm: Possible implications for fertilization. Dev. Biol. 223, 54-69.
  44. Moreno, R., Ramalho-Santos, J., Sutovsky, P., Chan, E. L. K., and Schatten G (2000) Vesicular traffic and golgi aparatus dynamics during mammalian spermatogenesis: Implications for acrosome architecture. Biol. Reprod., 63, 89-98
  45. Terada, Y., Luetjens, C. M., Sutovsky, P., and Schatten, G. (2000) Atypical decondensation of the sperm nucleus, delayed replication of the male genome and sex chromosome positioning following intracytoplasmic human sperm injection into golden hamster eggs: Does ICSI itself introduce chromosomal anomalies? Fertil. Steril., 74(3), 454-460
  46. Sutovsky, P., Moreno, R., Ramalho-Santos, J., Dominko, T., Simerly, C., and Schatten, G. (1999) Ubiquitin tag for sperm mitochondria. Nature 402, 371-372
  47. Simerly, C., Zoran, S. S., Payne, C., Dominko, T., Sutovsky, P., Navara, C. S., Salisbury, J. L., and Schatten, G. (1999) Biparental inheritance of G- tubulin during human fertilization: Molecular reconstitution of functional zygotic centrosomes in inseminated human oocytes and in cell-free extracts nucleated by human sperm. Mol. Biol. Cell 10, 2955-2969
  48. Sutovsky, P., Ramalho-Santos, J., Moreno, R. D., Oko, R., Hewitson, L., and Schatten, G. (1999) On-Stage Selection of Single Round Spermatids Using a Vital, Mitochondrion-Specific Fluorescent Probe MitoTrackerTM and High Resolution Differential Interference Contrast (DIC) Microscopy. Human Reprod., 14, 2301-2312
  49. Hewitson, L., Simerly, C., Sutovsky, P., Dominko, T., Takahashi, D., and Schatten, G. (1999) The fate of sperm components within the egg during fertilization. In: The Male Gamete: From Basic Science to Clinicla Applications. C. Gagnon, Ed., Cache River Press, Vienna, IL.
  50. Hewitson L., Dominko T., Takahashi D., Ramalho-Santos J., Sutovsky P., Fanton J., Jacob D., Monteith D., Neuringer M., Battaglia D., Simerly C., and Schatten., G. (1999) Births of ICSI monkeys: Unique checkpoints during the first cell cycle of fertilization. Nature Med. 5, 431-433
  51. Sutovsky, P., and Schatten, G. (2000) Paternal Contributions to the mammalian zygote: fertilization after sperm-egg fusion. Int. Rev. Cytol. 195, 1-65 (Invited article)
  52. Sutovsky, P., Manandhar, G., and Schatten, G. (1999) Biogenesis of the Centrosome During Mammalian Gametogenesis and Fertilization. Protoplasma 206, 249-262
  53. Sutovsky, P., and Schatten, G. (1998) Structural aspects of mammalian fertilization: New discoveries and Inspirations from the work of Daniel Szöllösi. Reprod. Nutr. Dev. 38, 629-641
  54. Srsen, V., Kalous, J., Nagyova, E., Sutovsky, P., King, W. A., and Motlik, J. (1998) Effects of follicle-stimulating hormone, bovine somatotrophin and okadaic acid on cumulus expansion and nuclear maturation of Blue fox (Alopex lagopus) oocytes in vitro. Zygote 6, 299-310
  55. Hewitson, L., Simerly, C., Sutovsky, P., Dominko,T., and Schatten, G. (1998) Molecular reconstitution and inheritance of the centrosome during fertilization: Implications for fertility. In: Lauria, A., et al. (eds.): Gametes: Development and Function. Serono Symposia, Rome, pp. 371-392
  56. Sutovsky, P., Simerly, C, Hewitson, L., and Schatten, G. (1998) Assembly of nuclear pore complexes and annulate lamellae promotes normal pronuclear development in fertilized mammalian oocytes. J. Cell Sci. 111, 2841-2854
  57. Manandhar, G., Sutovsky, P., Joshi, H. C., Stearns, T., and Schatten, G. (1998) Centrosome reduction during mouse spermiogenesis. Dev. Biol. 203, 424-434
  58. Simerly, C., Hewitson, L., Sutovsky, P., Takahashi, D., and Schatten, G. (1998) The role of centrosome and cytoskeleton during human fertilization: Implications for the new frontiers in infertility treatments. In: Treatment of Infertility: The New Frontiers. Communication Media for education
  59. Schatten, G., Hewitson, L., Simerly, C., Sutovsky, P., and Huszar, G. (1998) Cell and molecular biological challenges of ICSI: A.R.T. before science? J. Law, Med. & Ethics, 26: 5-13
  60. Sutovsky P., Flechon J.E. (1998) Cytoskeletal reorganization during cumulus expansion. In: Microscopy of Reproduction and Development. A Dynamic Approach. P. M. Motta, Ed., pp. 115-124.
  61. Sutovsky P, Oko R, Hewitson L, and Schatten G. (1997) The removal of the sperm perinuclear theca and its association with the bovine oocyte surface during fertilization. Dev. Biol., 188: 75-84
  62. Sutovsky P., and Schatten G. (1997) Depletion of glutathione during oocyte maturation reversibly blocks the decondensation of the male pronucleus and pronuclear apposition during fertilization. Biol. Reprod. 56:1503-1512
  63. Sutovsky P., Tengowski M.W., Navara C.S.,Zoran S.S., and Schatten G., (1997) Mitochondrial sheath movement and detachment in mammalian, but not non-mammalian, sperm induced by disulfide bond reduction. Mol. Reprod. Dev. 47: 79-86
  64. Simerly CR, Hewitson LC, Sutovsky P, Navara CS, Schatten G (1997) Predicted forms of male infertility as a result of disorders in the paternally inherited human centrosome. Proc. IX World Congr. Hum. Reprod.
  65. Simerly CR, Hewitson LC, Sutovsky P, Schatten G (1997) The inheritance, molecular dissection and reconstruction of the human centrosome during fertilization: consequences for infertility. In: Barrat C., de Jonge C., Mortimer D., Parinaud J. (eds), Genetics of human male fertility. EDK Press, Paris, p. 147-163
  66. Simerly CR, Haawisto AJ, Hewitson LC, Sutovsky P, Navara CS, Schatten G (1996) The molecular dissection and reconstitution of the centrosome during human fertilization: Implications for infertility. S. Afr. J. Sci. 92: 548-557
  67. Motlik J., Sutovsky P., Kalous J., Kalab P., Kubelka M., and Schultz R. M. (1996) Co-culture with pig membrana granulosa cells modulates the activity of cdc2 and MAP kinase in maturing cattle oocytes. Zygote 4: 247-256
  68. Navara C.S., Hewitson L., Simerly C.R., Sutovsky P., and Schatten G. (1996) The implications of a paternally derived centrosome during human fertilization: Consequences for reproduction and the treatment of male factor infertility. Am. J. Reprod. Imun. 37: 39-49
  69. Hewitson LC, Simerly CR, Sutovsky P, Navara CS, Tengowski MW, Schatten G. (1996) Advanced imaging of human fertilization. In: Visual atlas of sperm function for AR (Human). H. Sathannathan, Ed., 155-173
  70. Sutovsky P., Hewitson L., Simerly C.R., Schatten G. (1996) Molecular medical approaches for alleviating infertility and understanding assisted reproductive technologies. Proc. As. Amer. Phys. , 108/6: 432-443
  71. Sutovsky P, Hewitson LC, Simerly CR, Tengowski MW, Navara CS, Haavisto AJ, Schatten G. (1996) Intracytoplasmic sperm injection (ICSI) for Rhesus monkey fertilization results in unusual chromatin, cytoskeletal, and membrane events, but eventually leads to pronuclear development and sperm aster assembly. Human Reprod. 11:1703-1712
  72. Sutovsky P, Navara CS, Schatten G (1996). The fate of the sperm mitochondria and the incorporation, conversion and disassembly of the sperm tail structures during bovine fertilization in vitro. Biol. Reprod. 55: 1195-1205
  73. Hewitson LC, Simerly CR, Tengowski MW, Sutovsky P, Navara CS, Haavisto AJ, Schatten G. (1996) Microtubule and DNA configurations during Rhesus intracytoplasmic sperm injection: successes and failures. Biol. Reprod. 55:271-280
  74. Sutovsky P, Flechon JE, Pavlok A (1995) F-actin is involved in control of bovine cumulus expansion. Mol. Reprod. Dev. 41: 521-529
  75. Sutovsky P, Motlik J (1994) Cumulus expansion in mammals: An interplay between cumulus granulosa cell cytoskeleton, extracellular matrix and oocyte secretion. ARTA J. 6: 304-315
  76. Sutovsky P, Flechon JE, Pavlok A (1994) Microfilaments, microtubules and intermediate filaments fulfil differential roles in gonadotropin induced expansion of bovine cumulus oophorus. Reprod. Nutr. Develop. 34: 415-425
  77. Nagyová E, Kalous J, Sutovsky P, Motlík J; (1993) Is cAMP decrease essential for resumption of meiosis in mouse oocytes? Reprod. Nutr. Develop. 33: 419-428
  78. Sutovsky P, Fléchon J E, Fléchon B, Motlík J, Peynot N, Chesné P, Heyman Y,; (1993) Dynamic changes of gap junctions and cytoskeleton during in vitro culture of cattle oocyte cumulus complexes. Biol. Reprod., 49: 1277-1287
  79. Kanka J, Fléchon J E, Sutovsky P; (1993) Changes in RNA synthesis and poly(A) content of early rabbit and sheep embryos. Reprod. Nutr. Develop. 33: 465-474
  80. Sutovsky P, Jelínková L, Antalíková L, Motlík J; (1993) Ultrastructural cytochemistry of the nucleus and nucleolus in growing rabbit oocytes. Biol. Cell 77: 173-180
  81. Kalous J, Sutovsky P, Rimkevicová Z, Shioya Y, Lie B L, Motlík J; (1993) Pig membrana granulosa cells prevent resumption of meiosis in cattle oocytes. Mol. Reprod. Dev. 34: 58-64
  82. Procházka R, Kanka J, Sutovsky P, Fulka J, Motlík J; (1992) Development of pronuclei in pig oocytes activated by a single electric pulse. J. Reprod. Fert. 96: 725-734